Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows
ABSTRACT: Our aim was to determine the effects of P intake on P balance, serum parathyroid hormone (PTH) levels, and bone resorption during the final 4 wk prepartum and the first 8 wk of lactation. Sixty pregnant multiparous Holstein Friesian dairy cows were assigned to a randomized block design wit...
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Elsevier
2025-04-01
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| author | P. Keanthao R.M.A. Goselink J. Dijkstra A. Bannink J.T. Schonewille |
| author_facet | P. Keanthao R.M.A. Goselink J. Dijkstra A. Bannink J.T. Schonewille |
| author_sort | P. Keanthao |
| collection | DOAJ |
| description | ABSTRACT: Our aim was to determine the effects of P intake on P balance, serum parathyroid hormone (PTH) levels, and bone resorption during the final 4 wk prepartum and the first 8 wk of lactation. Sixty pregnant multiparous Holstein Friesian dairy cows were assigned to a randomized block design with repeated measurements and dietary treatments arranged according to a 2 × 2 factorial design. The experimental diets contained 3.6 (high phosphorus [HP]) or 2.2 (low phosphorus [LP]) g P/kg DM during the dry period (Dry-HP and Dry-LP, respectively), and 3.8 or 2.9 g P/kg DM during 56 d after calving (Lac-HP and Lac-LP, respectively). The level of dietary P of Dry-LP, expressed as g/kg DM, was 18% greater than recommended by the Dutch Central Bureau for Livestock Feeding (The Hague, the Netherlands), whereas the P content of Lac-LP was, across the 8 wk of lactation, 24% lower than recommended. Both P intake and fecal P excretion decreased in the dry period to increase again in subsequent lactation. Cows fed high dietary P excreted more P in the feces than cows fed low dietary P pre- and postpartum. Cows in both Dry-HP and Dry-LP were in positive P balance in the dry period. Cows in both Lac-LP and Lac-HP were in negative P balance after calving, with the negative P balance being more pronounced in Lac-LP than in Lac-HP. Serum concentrations of PTH and apparent total-tract OM and NDF digestibility were neither affected by any 2-way or 3-way interaction between time of sampling and dietary treatments nor by the P concentration of the experimental diets during the pre- and postpartum period. Before calving, serum carboxy-terminal collagen crosslink (CTX) concentrations were basically similar between Dry-HP and Dry-LP. After calving, serum CTX concentrations increased, with a more pronounced increase when Lac-LP was fed compared with Lac-HP. The results suggest that when feeding diets containing low P (2.9 g/kg DM) postpartum, cows excreted less P in the feces than at recommended dietary P (3.8 g P/kg DM) without a negative impact on OM and NDF digestibility. The increase in serum CTX concentrations, without increasing serum PTH concentrations upon feeding low P, indicate a prominent role of bone resorption to meet P demands in the first 8 wk postpartum. The present trial focused on the final 4 wk of gestation and the subsequent 8 wk of lactation, but long-term effects of low dietary P during early lactation on serum PTH and on bone P dynamics in mid and late lactation need to be further investigated. |
| format | Article |
| id | doaj-art-1ea771b04ec44b29ad70d874ed1d6803 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-1ea771b04ec44b29ad70d874ed1d68032025-08-20T02:11:42ZengElsevierJournal of Dairy Science0022-03022025-04-0110843602361210.3168/jds.2024-25463Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cowsP. Keanthao0R.M.A. Goselink1J. Dijkstra2A. Bannink3J.T. Schonewille4Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands; Department of Animal Science and Fishery, Rajamangala University of Technology Lanna, Tambon Chang Phueak, Mueang Chiang Mai District, Chiang Mai 50300, Thailand; Corresponding authorDepartment of Animal Nutrition, Wageningen Livestock Research, 6700 AH Wageningen, the NetherlandsAnimal Nutrition Group, Wageningen University and Research, 6700 AH Wageningen, the NetherlandsDepartment of Animal Nutrition, Wageningen Livestock Research, 6700 AH Wageningen, the NetherlandsDepartment of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the NetherlandsABSTRACT: Our aim was to determine the effects of P intake on P balance, serum parathyroid hormone (PTH) levels, and bone resorption during the final 4 wk prepartum and the first 8 wk of lactation. Sixty pregnant multiparous Holstein Friesian dairy cows were assigned to a randomized block design with repeated measurements and dietary treatments arranged according to a 2 × 2 factorial design. The experimental diets contained 3.6 (high phosphorus [HP]) or 2.2 (low phosphorus [LP]) g P/kg DM during the dry period (Dry-HP and Dry-LP, respectively), and 3.8 or 2.9 g P/kg DM during 56 d after calving (Lac-HP and Lac-LP, respectively). The level of dietary P of Dry-LP, expressed as g/kg DM, was 18% greater than recommended by the Dutch Central Bureau for Livestock Feeding (The Hague, the Netherlands), whereas the P content of Lac-LP was, across the 8 wk of lactation, 24% lower than recommended. Both P intake and fecal P excretion decreased in the dry period to increase again in subsequent lactation. Cows fed high dietary P excreted more P in the feces than cows fed low dietary P pre- and postpartum. Cows in both Dry-HP and Dry-LP were in positive P balance in the dry period. Cows in both Lac-LP and Lac-HP were in negative P balance after calving, with the negative P balance being more pronounced in Lac-LP than in Lac-HP. Serum concentrations of PTH and apparent total-tract OM and NDF digestibility were neither affected by any 2-way or 3-way interaction between time of sampling and dietary treatments nor by the P concentration of the experimental diets during the pre- and postpartum period. Before calving, serum carboxy-terminal collagen crosslink (CTX) concentrations were basically similar between Dry-HP and Dry-LP. After calving, serum CTX concentrations increased, with a more pronounced increase when Lac-LP was fed compared with Lac-HP. The results suggest that when feeding diets containing low P (2.9 g/kg DM) postpartum, cows excreted less P in the feces than at recommended dietary P (3.8 g P/kg DM) without a negative impact on OM and NDF digestibility. The increase in serum CTX concentrations, without increasing serum PTH concentrations upon feeding low P, indicate a prominent role of bone resorption to meet P demands in the first 8 wk postpartum. The present trial focused on the final 4 wk of gestation and the subsequent 8 wk of lactation, but long-term effects of low dietary P during early lactation on serum PTH and on bone P dynamics in mid and late lactation need to be further investigated.http://www.sciencedirect.com/science/article/pii/S0022030225000049transition cowbone resorptionparathyroid hormonedigestibility |
| spellingShingle | P. Keanthao R.M.A. Goselink J. Dijkstra A. Bannink J.T. Schonewille Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows Journal of Dairy Science transition cow bone resorption parathyroid hormone digestibility |
| title | Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows |
| title_full | Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows |
| title_fullStr | Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows |
| title_full_unstemmed | Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows |
| title_short | Effects of low-phosphorus diets on phosphorus balance, plasma concentrations of 25-hydroxyvitamin D3, and carboxy-terminal collagen crosslinks during the transition period in dairy cows |
| title_sort | effects of low phosphorus diets on phosphorus balance plasma concentrations of 25 hydroxyvitamin d3 and carboxy terminal collagen crosslinks during the transition period in dairy cows |
| topic | transition cow bone resorption parathyroid hormone digestibility |
| url | http://www.sciencedirect.com/science/article/pii/S0022030225000049 |
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