Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases
Endometrial cancer (EC) is the most common gynaecological malignancy in developed countries, with advanced- stage disease posing significant therapeutic challenges. Standard treatments, including surgery, radiotherapy and chemotherapy, have limited efficacy in recurrent or metastatic cases, necessit...
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BioExcel Publishing Ltd
2025-06-01
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| Series: | Drugs in Context |
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| Online Access: | https://www.drugsincontext.com/advancing-endometrial-cancer-treatment-exploring-immunotherapy-and-tyrosine-kinase-inhibitors-through-clinical-cases/ |
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| author | Vanda Salutari |
| author_facet | Vanda Salutari |
| author_sort | Vanda Salutari |
| collection | DOAJ |
| description | Endometrial cancer (EC) is the most common gynaecological malignancy in developed countries, with advanced- stage disease posing significant therapeutic challenges. Standard treatments, including surgery, radiotherapy and chemotherapy, have limited efficacy in recurrent or metastatic cases, necessitating novel therapeutic approaches. Recent molecular classifications of EC have identified subtypes with distinct prognostic and therapeutic implications, particularly those with high immunogenicity. Immunotherapy, specifically immune-checkpoint inhibitors targeting PD-1/ PD-L1, has transformed EC treatment. The combination of pembrolizumab, an anti-PD-1 monoclonal antibody, and lenvatinib, a tyrosine kinase inhibitor (TKI), has demonstrated superior efficacy over chemotherapy in the pivotal KEYNOTE-775 trial, significantly improving progression-free and overall survival in advanced EC. Additionally, dostarlimab has shown promise as a monotherapy for mismatch repair-deficient EC, expanding treatment options. This special series in Drugs in Context explores these advancements through clinical case studies, highlighting real-world applications of immunotherapy and TKIs. Cases illustrate treatment responses, challenges in managing toxicities and the evolving role of molecular profiling in personalizing therapy. As research progresses, integrating immunotherapy and TKIs into routine practice is expected to improve outcomes for patients with advanced EC, offering new hope in a previously limited therapeutic landscape.
This article is part of the New treatment options for advanced endometrial carcinoma Special Issue: https://www.drugsincontext.com/special_issues/new-treatment-options-for-advanced-endometrial-carcinoma |
| format | Article |
| id | doaj-art-1ea615c2f32a4177b25b9b1cc07afc95 |
| institution | Kabale University |
| issn | 1740-4398 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BioExcel Publishing Ltd |
| record_format | Article |
| series | Drugs in Context |
| spelling | doaj-art-1ea615c2f32a4177b25b9b1cc07afc952025-08-20T03:29:23ZengBioExcel Publishing LtdDrugs in Context1740-43982025-06-01141510.7573/dic.2025-4-4Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical casesVanda SalutariEndometrial cancer (EC) is the most common gynaecological malignancy in developed countries, with advanced- stage disease posing significant therapeutic challenges. Standard treatments, including surgery, radiotherapy and chemotherapy, have limited efficacy in recurrent or metastatic cases, necessitating novel therapeutic approaches. Recent molecular classifications of EC have identified subtypes with distinct prognostic and therapeutic implications, particularly those with high immunogenicity. Immunotherapy, specifically immune-checkpoint inhibitors targeting PD-1/ PD-L1, has transformed EC treatment. The combination of pembrolizumab, an anti-PD-1 monoclonal antibody, and lenvatinib, a tyrosine kinase inhibitor (TKI), has demonstrated superior efficacy over chemotherapy in the pivotal KEYNOTE-775 trial, significantly improving progression-free and overall survival in advanced EC. Additionally, dostarlimab has shown promise as a monotherapy for mismatch repair-deficient EC, expanding treatment options. This special series in Drugs in Context explores these advancements through clinical case studies, highlighting real-world applications of immunotherapy and TKIs. Cases illustrate treatment responses, challenges in managing toxicities and the evolving role of molecular profiling in personalizing therapy. As research progresses, integrating immunotherapy and TKIs into routine practice is expected to improve outcomes for patients with advanced EC, offering new hope in a previously limited therapeutic landscape. This article is part of the New treatment options for advanced endometrial carcinoma Special Issue: https://www.drugsincontext.com/special_issues/new-treatment-options-for-advanced-endometrial-carcinomahttps://www.drugsincontext.com/advancing-endometrial-cancer-treatment-exploring-immunotherapy-and-tyrosine-kinase-inhibitors-through-clinical-cases/immune checkpoint inhibitorsendometrial cancertyrosine kinase inhibitors |
| spellingShingle | Vanda Salutari Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases Drugs in Context immune checkpoint inhibitors endometrial cancer tyrosine kinase inhibitors |
| title | Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases |
| title_full | Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases |
| title_fullStr | Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases |
| title_full_unstemmed | Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases |
| title_short | Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases |
| title_sort | advancing endometrial cancer treatment exploring immunotherapy and tyrosine kinase inhibitors through clinical cases |
| topic | immune checkpoint inhibitors endometrial cancer tyrosine kinase inhibitors |
| url | https://www.drugsincontext.com/advancing-endometrial-cancer-treatment-exploring-immunotherapy-and-tyrosine-kinase-inhibitors-through-clinical-cases/ |
| work_keys_str_mv | AT vandasalutari advancingendometrialcancertreatmentexploringimmunotherapyandtyrosinekinaseinhibitorsthroughclinicalcases |