Divergence in photoreceptor cell death and neuroinflammation in transvitreal and transscleral subretinal delivery in mice

Divergence in photoreceptor cell death and neuroinflammation in transvitreal and transscleral subretinal delivery in mice

Abstract Subretinal injections provide direct access to photoreceptors and RPE, which is crucial for the delivery of gene therapy and neuroprotective approaches. To access the subretinal space, transvitreal (TV) and transscleral (TS) subretinal injections have been widely used in humans and animal m...

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Bibliographic Details
Main Authors: Daniel E. Maidana, Sara Pastor Puente, Catherine Wang, Shivam Chandra, Lucia Gonzalez-Buendia, Eleftherios Paschalis Ilios, Andrius Kazlauskas, Demetrios G. Vavvas
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Inflammation
Subjects:
Retinal detachment
Outer nuclear layer
CD11b
CX3CR1
CCR2
Gliosis
Online Access:https://doi.org/10.1186/s12950-025-00433-1
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