Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials
Melasma is a chronic pigmentation disorder that is difficult to treat due to its recurrent nature. This meta-analysis evaluated the efficacy and safety of chemical peels and laser treatments in reducing pigmentation and associated risks like post-inflammatory hyperpigmentation (PIH). To compare chem...
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Korean Society of Korean Cosmetic Surgery and medicine
2024-12-01
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| Series: | Journal of Cosmetic Medicine |
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| Online Access: | http://www.jcosmetmed.org/journal/view.html?doi=10.25056/JCM.2024.8.2.81 |
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| author | Ingyu Lee SeoWon Kang JinHan Lee Hyungin Cho Ki Won Lee Dongkeun Lim |
| author_facet | Ingyu Lee SeoWon Kang JinHan Lee Hyungin Cho Ki Won Lee Dongkeun Lim |
| author_sort | Ingyu Lee |
| collection | DOAJ |
| description | Melasma is a chronic pigmentation disorder that is difficult to treat due to its recurrent nature. This meta-analysis evaluated the efficacy and safety of chemical peels and laser treatments in reducing pigmentation and associated risks like post-inflammatory hyperpigmentation (PIH). To compare chemical peels and laser treatments for melasma, focusing on their effectiveness in reducing pigmentation severity (Melasma Area and Severity Index) and assessing risks like PIH. We analyzed 15 randomized controlled trials comparing outcomes of chemical peels (e.g., glycolic acid, salicylic acid) and laser treatments (e.g., Q-switched Nd, fractional lasers). Outcomes included melasma severity reduction, PIH incidence, and patient satisfaction. Data were synthesized using standardized mean differences (SMD) with 95% confidence intervals (CI), and forest and funnel plots were used to evaluate efficacy and publication bias. Lasers showed higher efficacy in reducing melasma severity (SMD=0.82, 95% CI [0.60, 1.04], p<0.001) than chemical peels (SMD=0.65, 95% CI [0.45, 0.85], p=0.015). However, lasers had a higher risk of PIH, especially in darker skin types (Fitzpatrick IV-VI), while chemical peels were safer with fewer complications. Laser treatments effectively reduce melasma severity but increase PIH risk. Chemical peels, though slower, are safer for patients prone to adverse effects. Combination therapies and maintenance strategies may improve long-term outcomes in melasma |
| format | Article |
| id | doaj-art-1ea02dc210ff4bb9b1e4761131ee8ef0 |
| institution | Kabale University |
| issn | 2586-0585 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korean Society of Korean Cosmetic Surgery and medicine |
| record_format | Article |
| series | Journal of Cosmetic Medicine |
| spelling | doaj-art-1ea02dc210ff4bb9b1e4761131ee8ef02025-01-06T05:22:11ZengKorean Society of Korean Cosmetic Surgery and medicineJournal of Cosmetic Medicine2586-05852024-12-0182818710.25056/JCM.2024.8.2.81JCM.2024.8.2.81Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trialsIngyu Lee0SeoWon Kang1JinHan Lee2Hyungin Cho3Ki Won Lee4Dongkeun Lim5Department of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Orthopedic Surgery, Eulji University Medical Center, Seoul, Rep. of KoreaMelasma is a chronic pigmentation disorder that is difficult to treat due to its recurrent nature. This meta-analysis evaluated the efficacy and safety of chemical peels and laser treatments in reducing pigmentation and associated risks like post-inflammatory hyperpigmentation (PIH). To compare chemical peels and laser treatments for melasma, focusing on their effectiveness in reducing pigmentation severity (Melasma Area and Severity Index) and assessing risks like PIH. We analyzed 15 randomized controlled trials comparing outcomes of chemical peels (e.g., glycolic acid, salicylic acid) and laser treatments (e.g., Q-switched Nd, fractional lasers). Outcomes included melasma severity reduction, PIH incidence, and patient satisfaction. Data were synthesized using standardized mean differences (SMD) with 95% confidence intervals (CI), and forest and funnel plots were used to evaluate efficacy and publication bias. Lasers showed higher efficacy in reducing melasma severity (SMD=0.82, 95% CI [0.60, 1.04], p<0.001) than chemical peels (SMD=0.65, 95% CI [0.45, 0.85], p=0.015). However, lasers had a higher risk of PIH, especially in darker skin types (Fitzpatrick IV-VI), while chemical peels were safer with fewer complications. Laser treatments effectively reduce melasma severity but increase PIH risk. Chemical peels, though slower, are safer for patients prone to adverse effects. Combination therapies and maintenance strategies may improve long-term outcomes in melasmahttp://www.jcosmetmed.org/journal/view.html?doi=10.25056/JCM.2024.8.2.81chemical peels; laser treatments; melasma; meta-analysis; post-inflammatory hyperpigmentation; randomized controlled trials |
| spellingShingle | Ingyu Lee SeoWon Kang JinHan Lee Hyungin Cho Ki Won Lee Dongkeun Lim Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials Journal of Cosmetic Medicine chemical peels; laser treatments; melasma; meta-analysis; post-inflammatory hyperpigmentation; randomized controlled trials |
| title | Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials |
| title_full | Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials |
| title_fullStr | Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials |
| title_short | Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials |
| title_sort | comparative efficacy of chemical peels and laser treatments in melasma a meta analysis of randomized controlled trials |
| topic | chemical peels; laser treatments; melasma; meta-analysis; post-inflammatory hyperpigmentation; randomized controlled trials |
| url | http://www.jcosmetmed.org/journal/view.html?doi=10.25056/JCM.2024.8.2.81 |
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