Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms
Lipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER). This study was conducted to prove a correlation between the detection of alimentary pulmonary fat phagocytosis and an increasing amount of proximal...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/673637 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850230657235550208 |
|---|---|
| author | R. Kitz H. J. Boehles M. Rosewich M. A. Rose |
| author_facet | R. Kitz H. J. Boehles M. Rosewich M. A. Rose |
| author_sort | R. Kitz |
| collection | DOAJ |
| description | Lipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER). This study was conducted to prove a correlation between the detection of alimentary pulmonary fat phagocytosis and an increasing amount of proximal gastroesophageal reflux. It was assumed that proximal gastroesophageal reflux better correlates with aspiration than distal GER. Patients from 6 months to 16 years with unexplained recurrent wheezy bronchitis and bronchial hyperreactivity, or recurrent pneumonia with chronic cough underwent 24-hour double-channel pH monitoring and bronchoscopy with bronchoalveolar lavage (BAL). Aspiration of gastric content was determined by counting lipid laden alveolar macrophages from BAL specimens. There were no correlations between any pH-monitoring parameters and counts of lipid-laden macrophages in the whole study population, even when restricting analysis to those with abnormal reflux index expressing clinically significant GER. Quantifying lipid-laden alveolar macrophages from BAL in children with gastroesophageal-related respiratory disorders does not have an acceptable specificity to prove chronic aspiration as an underlying etiology. Therefore, research for other markers of pulmonary aspiration is needed. |
| format | Article |
| id | doaj-art-1ea0058c12104592aa5cef592136ce7c |
| institution | OA Journals |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-1ea0058c12104592aa5cef592136ce7c2025-08-20T02:03:47ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/673637673637Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory SymptomsR. Kitz0H. J. Boehles1M. Rosewich2M. A. Rose3Pulmonology, Allergy and Cystic Fibrosis, Children’s Hospital, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, GermanyPulmonology, Allergy and Cystic Fibrosis, Children’s Hospital, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, GermanyPulmonology, Allergy and Cystic Fibrosis, Children’s Hospital, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, GermanyPulmonology, Allergy and Cystic Fibrosis, Children’s Hospital, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, GermanyLipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER). This study was conducted to prove a correlation between the detection of alimentary pulmonary fat phagocytosis and an increasing amount of proximal gastroesophageal reflux. It was assumed that proximal gastroesophageal reflux better correlates with aspiration than distal GER. Patients from 6 months to 16 years with unexplained recurrent wheezy bronchitis and bronchial hyperreactivity, or recurrent pneumonia with chronic cough underwent 24-hour double-channel pH monitoring and bronchoscopy with bronchoalveolar lavage (BAL). Aspiration of gastric content was determined by counting lipid laden alveolar macrophages from BAL specimens. There were no correlations between any pH-monitoring parameters and counts of lipid-laden macrophages in the whole study population, even when restricting analysis to those with abnormal reflux index expressing clinically significant GER. Quantifying lipid-laden alveolar macrophages from BAL in children with gastroesophageal-related respiratory disorders does not have an acceptable specificity to prove chronic aspiration as an underlying etiology. Therefore, research for other markers of pulmonary aspiration is needed.http://dx.doi.org/10.1155/2012/673637 |
| spellingShingle | R. Kitz H. J. Boehles M. Rosewich M. A. Rose Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms Pulmonary Medicine |
| title | Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms |
| title_full | Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms |
| title_fullStr | Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms |
| title_full_unstemmed | Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms |
| title_short | Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory Symptoms |
| title_sort | lipid laden alveolar macrophages and ph monitoring in gastroesophageal reflux related respiratory symptoms |
| url | http://dx.doi.org/10.1155/2012/673637 |
| work_keys_str_mv | AT rkitz lipidladenalveolarmacrophagesandphmonitoringingastroesophagealrefluxrelatedrespiratorysymptoms AT hjboehles lipidladenalveolarmacrophagesandphmonitoringingastroesophagealrefluxrelatedrespiratorysymptoms AT mrosewich lipidladenalveolarmacrophagesandphmonitoringingastroesophagealrefluxrelatedrespiratorysymptoms AT marose lipidladenalveolarmacrophagesandphmonitoringingastroesophagealrefluxrelatedrespiratorysymptoms |