Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer
Abstract Background Preoperative and early postoperative serum carcinoembryonic antigen (CEA) levels are known prognostic factors in rectal cancer. Recently, a large‐scale study on colon cancer revealed that “preoperatively elevated and postoperatively normalized CEA levels” is not an indicator of p...
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Wiley
2020-01-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2758 |
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| author | Yuya Nakamura Dai Shida Taro Tanabe Yasuyuki Takamizawa Jun Imaizumi Yuka Ahiko Ryohei Sakamoto Konosuke Moritani Shunsuke Tsukamoto Yukihide Kanemitsu |
| author_facet | Yuya Nakamura Dai Shida Taro Tanabe Yasuyuki Takamizawa Jun Imaizumi Yuka Ahiko Ryohei Sakamoto Konosuke Moritani Shunsuke Tsukamoto Yukihide Kanemitsu |
| author_sort | Yuya Nakamura |
| collection | DOAJ |
| description | Abstract Background Preoperative and early postoperative serum carcinoembryonic antigen (CEA) levels are known prognostic factors in rectal cancer. Recently, a large‐scale study on colon cancer revealed that “preoperatively elevated and postoperatively normalized CEA levels” is not an indicator of poor prognosis. However, whether this hold true in rectal cancer patients is unknown. This study aimed to investigate the prognostic significance of preoperatively elevated and postoperatively normalized CEA levels in rectal cancer patients undergoing curative resection. Methods Subjects were consecutive stage I‐III rectal cancer patients who underwent curative resection without preoperative treatment at National Cancer Center Hospital between 2000 and 2015. Overall survival (OS) and the hazard function of recurrence or death were analyzed according to the CEA levels, as follows: normal preoperative CEA (normal group), preoperatively elevated but postoperatively normalized CEA (normalized group), and preoperatively and postoperatively elevated CEA (elevated group). Results The normalized group (n =235) had worse OS (HR 1.49, 95% CI 1.08‐2.04; P = .0142) compared to the normal group (n = 1208), and better OS compared to the elevated group (n = 47) (HR 0.53, 95% CI 0.31‐0.91; P = .0208). The elevated group had the highest and earliest peak in hazard function, followed by the normalized group and the normal group, with median times to recurrence of 8.8, 15.5, and 18.5 months, respectively (P = .0223). Conclusions Prognosis after resection of rectal cancer was worse in patients with preoperatively elevated and postoperatively normalized CEA compared to those with normal preoperative CEA. Patients with elevated preoperative CEA might require intensive follow‐up even if levels normalize after resection, especially in earlier periods, for early detection of recurrence. |
| format | Article |
| id | doaj-art-1e9c8d8fc703408f9bc32f8a693441ea |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-1e9c8d8fc703408f9bc32f8a693441ea2025-08-25T10:14:05ZengWileyCancer Medicine2045-76342020-01-019265366210.1002/cam4.2758Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancerYuya Nakamura0Dai Shida1Taro Tanabe2Yasuyuki Takamizawa3Jun Imaizumi4Yuka Ahiko5Ryohei Sakamoto6Konosuke Moritani7Shunsuke Tsukamoto8Yukihide Kanemitsu9Department of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanAbstract Background Preoperative and early postoperative serum carcinoembryonic antigen (CEA) levels are known prognostic factors in rectal cancer. Recently, a large‐scale study on colon cancer revealed that “preoperatively elevated and postoperatively normalized CEA levels” is not an indicator of poor prognosis. However, whether this hold true in rectal cancer patients is unknown. This study aimed to investigate the prognostic significance of preoperatively elevated and postoperatively normalized CEA levels in rectal cancer patients undergoing curative resection. Methods Subjects were consecutive stage I‐III rectal cancer patients who underwent curative resection without preoperative treatment at National Cancer Center Hospital between 2000 and 2015. Overall survival (OS) and the hazard function of recurrence or death were analyzed according to the CEA levels, as follows: normal preoperative CEA (normal group), preoperatively elevated but postoperatively normalized CEA (normalized group), and preoperatively and postoperatively elevated CEA (elevated group). Results The normalized group (n =235) had worse OS (HR 1.49, 95% CI 1.08‐2.04; P = .0142) compared to the normal group (n = 1208), and better OS compared to the elevated group (n = 47) (HR 0.53, 95% CI 0.31‐0.91; P = .0208). The elevated group had the highest and earliest peak in hazard function, followed by the normalized group and the normal group, with median times to recurrence of 8.8, 15.5, and 18.5 months, respectively (P = .0223). Conclusions Prognosis after resection of rectal cancer was worse in patients with preoperatively elevated and postoperatively normalized CEA compared to those with normal preoperative CEA. Patients with elevated preoperative CEA might require intensive follow‐up even if levels normalize after resection, especially in earlier periods, for early detection of recurrence.https://doi.org/10.1002/cam4.2758carcinoembryonic antigenpostoperative CEApreoperative CEAprognostic factorrectal cancer |
| spellingShingle | Yuya Nakamura Dai Shida Taro Tanabe Yasuyuki Takamizawa Jun Imaizumi Yuka Ahiko Ryohei Sakamoto Konosuke Moritani Shunsuke Tsukamoto Yukihide Kanemitsu Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer Cancer Medicine carcinoembryonic antigen postoperative CEA preoperative CEA prognostic factor rectal cancer |
| title | Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer |
| title_full | Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer |
| title_fullStr | Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer |
| title_full_unstemmed | Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer |
| title_short | Prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage I‐III rectal cancer |
| title_sort | prognostic impact of preoperatively elevated and postoperatively normalized carcinoembryonic antigen levels following curative resection of stage i iii rectal cancer |
| topic | carcinoembryonic antigen postoperative CEA preoperative CEA prognostic factor rectal cancer |
| url | https://doi.org/10.1002/cam4.2758 |
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