Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality.
<h4>Background</h4>Poor diet increases the risk of both colorectal cancer and type 2 diabetes. We investigated the role of diet in the association between diabetes and colorectal cancer.<h4>Methods</h4>We analyzed data from 484,020 individuals, aged 50-71 years who participat...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0074616 |
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| author | Soghra Jarvandi Nicholas O Davidson Mario Schootman |
| author_facet | Soghra Jarvandi Nicholas O Davidson Mario Schootman |
| author_sort | Soghra Jarvandi |
| collection | DOAJ |
| description | <h4>Background</h4>Poor diet increases the risk of both colorectal cancer and type 2 diabetes. We investigated the role of diet in the association between diabetes and colorectal cancer.<h4>Methods</h4>We analyzed data from 484,020 individuals, aged 50-71 years who participated in the prospective National Institutes of Health-AARP Diet and Health Study and were cancer free at baseline (1995-1996). History of diabetes was self-reported. Diet quality was measured with the Healthy Eating Index-2005 (HEI-2005), using a self-administered food-frequency questionnaire. Cox regression models were constructed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of first primary incident colorectal cancer, overall and by anatomical location.<h4>Results</h4>During an average follow-up of 9.2 years, we identified 7,598 new cases of colorectal cancer. After controlling for non-dietary confounders, diabetes was associated with increased risk of colorectal cancer (HR 1.27, 95% CI: 1.18, 1.36). Further adjustment for diet quality did not attenuate this association. Diabetes was associated with a HR of 1.23 (95% CI: 1.07, 1.40) in individuals with good diet (quartile 4 of HEI-2005) and 1.58 (95% CI: 1.34, 1.86) in those with poor diet (quartile 1 of HEI-2005), compared to those with no diabetes and good diet. Moreover, diabetes was associated with a stronger risk of proximal than distal colon cancer (HR: 1.33 vs. HR: 1.20), while poor diet was associated with a weaker risk of proximal colon cancer (HR: 1.18 vs. HR: 1.46).<h4>Conclusion</h4>Diabetes and poor diet, independently and additively are associated with the increased risk of colorectal cancer. |
| format | Article |
| id | doaj-art-1e98efa629fb401e833ed0dae36d4166 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-1e98efa629fb401e833ed0dae36d41662025-08-20T02:33:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7461610.1371/journal.pone.0074616Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality.Soghra JarvandiNicholas O DavidsonMario Schootman<h4>Background</h4>Poor diet increases the risk of both colorectal cancer and type 2 diabetes. We investigated the role of diet in the association between diabetes and colorectal cancer.<h4>Methods</h4>We analyzed data from 484,020 individuals, aged 50-71 years who participated in the prospective National Institutes of Health-AARP Diet and Health Study and were cancer free at baseline (1995-1996). History of diabetes was self-reported. Diet quality was measured with the Healthy Eating Index-2005 (HEI-2005), using a self-administered food-frequency questionnaire. Cox regression models were constructed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of first primary incident colorectal cancer, overall and by anatomical location.<h4>Results</h4>During an average follow-up of 9.2 years, we identified 7,598 new cases of colorectal cancer. After controlling for non-dietary confounders, diabetes was associated with increased risk of colorectal cancer (HR 1.27, 95% CI: 1.18, 1.36). Further adjustment for diet quality did not attenuate this association. Diabetes was associated with a HR of 1.23 (95% CI: 1.07, 1.40) in individuals with good diet (quartile 4 of HEI-2005) and 1.58 (95% CI: 1.34, 1.86) in those with poor diet (quartile 1 of HEI-2005), compared to those with no diabetes and good diet. Moreover, diabetes was associated with a stronger risk of proximal than distal colon cancer (HR: 1.33 vs. HR: 1.20), while poor diet was associated with a weaker risk of proximal colon cancer (HR: 1.18 vs. HR: 1.46).<h4>Conclusion</h4>Diabetes and poor diet, independently and additively are associated with the increased risk of colorectal cancer.https://doi.org/10.1371/journal.pone.0074616 |
| spellingShingle | Soghra Jarvandi Nicholas O Davidson Mario Schootman Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. PLoS ONE |
| title | Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. |
| title_full | Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. |
| title_fullStr | Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. |
| title_full_unstemmed | Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. |
| title_short | Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. |
| title_sort | increased risk of colorectal cancer in type 2 diabetes is independent of diet quality |
| url | https://doi.org/10.1371/journal.pone.0074616 |
| work_keys_str_mv | AT soghrajarvandi increasedriskofcolorectalcancerintype2diabetesisindependentofdietquality AT nicholasodavidson increasedriskofcolorectalcancerintype2diabetesisindependentofdietquality AT marioschootman increasedriskofcolorectalcancerintype2diabetesisindependentofdietquality |