Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus
Background and aimsJuvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment. Patients with JSLE exhibit more severe disease when compared to patients with adult-onset SLE. This study aimed to evaluate the preva...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1429337/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087099768045568 |
|---|---|
| author | Su Jin Park Moon Bae Ahn Dae Chul Jeong |
| author_facet | Su Jin Park Moon Bae Ahn Dae Chul Jeong |
| author_sort | Su Jin Park |
| collection | DOAJ |
| description | Background and aimsJuvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment. Patients with JSLE exhibit more severe disease when compared to patients with adult-onset SLE. This study aimed to evaluate the prevalence of endocrine and metabolic comorbidities in patients with JSLE, and analyze the factors associated with each comorbidity.MethodsAnthropometric, clinical, laboratory data, and the details of glucocorticoids and disease-modifying anti-rheumatic drugs use were collected.ResultsA total of 57 patients with JSLE (48 girls and 9 boys) were included in this study. Endocrine and metabolic comorbidities were observed in 64.9% of the patients. The most prevalent comorbidities were dyslipidemia (40.4%), being overweight or obese (26.3%), subclinical hypothyroidism (24.6%), autoimmune thyroid disease (AITD) (21.1%), and low bone mass (20.9%). The risk of dyslipidemia and AITD increased in patients who were overweight or obese. The risk of being overweight or obese was associated with skin involvement at diagnosis and rheumatoid factor positivity. Younger age at diagnosis and longer duration of glucocorticoid exposure increased the risk of low bone mass. The overall prevalence of endocrine and metabolic comorbidities was associated with short stature at diagnosis, being overweight or obese at follow-up, skin involvement at diagnosis, and rheumatoid factor positivity.ConclusionPatients with JSLE have higher burdens of endocrine and metabolic comorbidities and should be routinely monitored. Prevention of obesity may be helpful in lowering the risk of comorbidities. |
| format | Article |
| id | doaj-art-1e97761e4b7e4dfdadfe91d0cfe7f7f1 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-1e97761e4b7e4dfdadfe91d0cfe7f7f12025-02-06T07:09:22ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14293371429337Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosusSu Jin Park0Moon Bae Ahn1Dae Chul Jeong2Division of Endocrinology, Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDivision of Endocrinology, Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDivision of Rheumatology, Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaBackground and aimsJuvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment. Patients with JSLE exhibit more severe disease when compared to patients with adult-onset SLE. This study aimed to evaluate the prevalence of endocrine and metabolic comorbidities in patients with JSLE, and analyze the factors associated with each comorbidity.MethodsAnthropometric, clinical, laboratory data, and the details of glucocorticoids and disease-modifying anti-rheumatic drugs use were collected.ResultsA total of 57 patients with JSLE (48 girls and 9 boys) were included in this study. Endocrine and metabolic comorbidities were observed in 64.9% of the patients. The most prevalent comorbidities were dyslipidemia (40.4%), being overweight or obese (26.3%), subclinical hypothyroidism (24.6%), autoimmune thyroid disease (AITD) (21.1%), and low bone mass (20.9%). The risk of dyslipidemia and AITD increased in patients who were overweight or obese. The risk of being overweight or obese was associated with skin involvement at diagnosis and rheumatoid factor positivity. Younger age at diagnosis and longer duration of glucocorticoid exposure increased the risk of low bone mass. The overall prevalence of endocrine and metabolic comorbidities was associated with short stature at diagnosis, being overweight or obese at follow-up, skin involvement at diagnosis, and rheumatoid factor positivity.ConclusionPatients with JSLE have higher burdens of endocrine and metabolic comorbidities and should be routinely monitored. Prevention of obesity may be helpful in lowering the risk of comorbidities.https://www.frontiersin.org/articles/10.3389/fmed.2025.1429337/fullsystemic lupus erythematosusjuvenileendocrine system diseasesmetabolic diseasescomorbidities |
| spellingShingle | Su Jin Park Moon Bae Ahn Dae Chul Jeong Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus Frontiers in Medicine systemic lupus erythematosus juvenile endocrine system diseases metabolic diseases comorbidities |
| title | Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus |
| title_full | Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus |
| title_fullStr | Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus |
| title_full_unstemmed | Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus |
| title_short | Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus |
| title_sort | endocrine and metabolic comorbidities in juvenile onset systemic lupus erythematosus |
| topic | systemic lupus erythematosus juvenile endocrine system diseases metabolic diseases comorbidities |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1429337/full |
| work_keys_str_mv | AT sujinpark endocrineandmetaboliccomorbiditiesinjuvenileonsetsystemiclupuserythematosus AT moonbaeahn endocrineandmetaboliccomorbiditiesinjuvenileonsetsystemiclupuserythematosus AT daechuljeong endocrineandmetaboliccomorbiditiesinjuvenileonsetsystemiclupuserythematosus |