Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis
Objective: This study aimed to compare the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values in patients with euthyroid Hashimoto's thyroiditis (HT) with healthy control subjects. Methods: This was a single-center, retrospective, cross-sectional study conducted...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2023-09-01
|
| Series: | Medeniyet Medical Journal |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-41882 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832581935619112960 |
|---|---|
| author | Hacer Nur RESBER Mumtaz TAKIR Cundullah TORUN |
| author_facet | Hacer Nur RESBER Mumtaz TAKIR Cundullah TORUN |
| author_sort | Hacer Nur RESBER |
| collection | DOAJ |
| description | Objective: This study aimed to compare the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values in patients with euthyroid Hashimoto's thyroiditis (HT) with healthy control subjects.
Methods: This was a single-center, retrospective, cross-sectional study conducted on obese patients aged 18 years and over. The medical records of patients who presented with complaints of being overweight at the obesity clinic between April 2017 and May 2019 were examined. Patients and healthy individuals were included in the study consecutively until the sample sizes reached saturation. Patients with diabetes, cardiovascular disease, chronic inflammatory disease, and malignancy were excluded from the study. The patients' anthropometric measurements, smoking status, blood examination, and thyroid ultrasounds were evaluated. The difference in means between the groups was calculated using the Mann-Whitney U test.
Results: The study included 179 participants, consisting of 93 patients and 86 healthy controls. The mean age was 46.6+-14.1 years, with most females (91.6%). Although the NLR and PLR values in patients were higher than those in the control group, the difference did not reach statistical significance (p=0.427 and p=0.089, respectively). Furthermore, no significant difference was observed in NLR (p=0.191) and PLR (p=0.668) values between levothyroxine-treated and untreated patients. Correlation analysis revealed weak positive associations between C-reactive protein and thyroid peroxidase antibodies (p<0.05), neutrophils (p<0.01), platelets (p<0.01), and NLR (p<0.05).
Conclusions: The findings of this study suggest that NLR and PLR may not serve as effective indicators of systemic inflammation in patients with euthyroid HT, nor do they adequately assess the impact of levothyroxine usage on systemic inflammation. |
| format | Article |
| id | doaj-art-1e97281163da4f09b40398ed77819893 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-1e97281163da4f09b40398ed778198932025-01-30T07:02:58ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062023-09-0138320420910.4274/MMJ.galenos.2023.41882MEDJ-41882Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's ThyroiditisHacer Nur RESBER0Mumtaz TAKIR1Cundullah TORUN2Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Family Medicine, Istanbul, TurkeyIstanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Endocrinology, Istanbul, TurkeyIstanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Internal Medicine, Istanbul, TurkeyObjective: This study aimed to compare the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values in patients with euthyroid Hashimoto's thyroiditis (HT) with healthy control subjects. Methods: This was a single-center, retrospective, cross-sectional study conducted on obese patients aged 18 years and over. The medical records of patients who presented with complaints of being overweight at the obesity clinic between April 2017 and May 2019 were examined. Patients and healthy individuals were included in the study consecutively until the sample sizes reached saturation. Patients with diabetes, cardiovascular disease, chronic inflammatory disease, and malignancy were excluded from the study. The patients' anthropometric measurements, smoking status, blood examination, and thyroid ultrasounds were evaluated. The difference in means between the groups was calculated using the Mann-Whitney U test. Results: The study included 179 participants, consisting of 93 patients and 86 healthy controls. The mean age was 46.6+-14.1 years, with most females (91.6%). Although the NLR and PLR values in patients were higher than those in the control group, the difference did not reach statistical significance (p=0.427 and p=0.089, respectively). Furthermore, no significant difference was observed in NLR (p=0.191) and PLR (p=0.668) values between levothyroxine-treated and untreated patients. Correlation analysis revealed weak positive associations between C-reactive protein and thyroid peroxidase antibodies (p<0.05), neutrophils (p<0.01), platelets (p<0.01), and NLR (p<0.05). Conclusions: The findings of this study suggest that NLR and PLR may not serve as effective indicators of systemic inflammation in patients with euthyroid HT, nor do they adequately assess the impact of levothyroxine usage on systemic inflammation.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-41882hematological indicessystemic inflammationhypothyroidism |
| spellingShingle | Hacer Nur RESBER Mumtaz TAKIR Cundullah TORUN Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis Medeniyet Medical Journal hematological indices systemic inflammation hypothyroidism |
| title | Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis |
| title_full | Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis |
| title_fullStr | Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis |
| title_full_unstemmed | Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis |
| title_short | Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis |
| title_sort | neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in the patients with euthyroid hashimoto s thyroiditis |
| topic | hematological indices systemic inflammation hypothyroidism |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-41882 |
| work_keys_str_mv | AT hacernurresber neutrophiltolymphocyteratioandplatelettolymphocyteratiointhepatientswitheuthyroidhashimotosthyroiditis AT mumtaztakir neutrophiltolymphocyteratioandplatelettolymphocyteratiointhepatientswitheuthyroidhashimotosthyroiditis AT cundullahtorun neutrophiltolymphocyteratioandplatelettolymphocyteratiointhepatientswitheuthyroidhashimotosthyroiditis |