Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation

Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation

Abstract Background Clinical therapeutic approaches to prevent and treat renal injury in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) induced by calcium oxalate (CaOx) are limited. As a pivotal deacetylase, Sirtuin1 (Sirt1) exhibits notably anti‐inflammatory effects, but...

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Main Authors: Xiangyang Yao, Haoran Liu, Chen Duan, Yangjun Zhang, Xiaoliang Wu, Bo Li, Sheng Li, Yan Gong, Tongzu Liu, Xinghuan Wang, Hua Xu
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Clinical and Translational Medicine
Subjects:
calcium oxalate nephropathy
itaconate
macrophage
Sirt1
Online Access:https://doi.org/10.1002/ctm2.70450
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