Lactate in ferroptosis regulation: A new perspective on tumor progression and therapy

Lactate in ferroptosis regulation: A new perspective on tumor progression and therapy

Ferroptosis is a type of regulated cell death induced by iron-dependent lipid peroxidation, which is tightly regulated by metabolism. Lactate is a byproduct of glycolysis that regulates energy, fatty acid metabolism, and redox homeostasis as a fuel or signaling molecule. The role of lactate in ferro...

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Bibliographic Details
Main Authors: Nan Wu, Xiaoqi Wei, Shuang Yu, Lina Yang, Xiaowen Zhang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Lactate
Lactylation
Ferroptosis
Chemodynamic therapy
Tumor progression
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182500266X
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