Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience
Familial Mediterranean Fever (FMF) is characterized by recurrent febrile attacks and serositis. While colchicine is the primary treatment for FMF, some patients present resistance or intolerance with respect to this drug. Anakinra—an IL-1 receptor antagonist—has demonstrated efficacy in colchicine-r...
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MDPI AG
2025-04-01
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| author | Tuğba Ocak Havva Nur Köse Burcu Yağız Belkıs Nihan Coşkun Ediz Dalkılıç Yavuz Pehlivan |
| author_facet | Tuğba Ocak Havva Nur Köse Burcu Yağız Belkıs Nihan Coşkun Ediz Dalkılıç Yavuz Pehlivan |
| author_sort | Tuğba Ocak |
| collection | DOAJ |
| description | Familial Mediterranean Fever (FMF) is characterized by recurrent febrile attacks and serositis. While colchicine is the primary treatment for FMF, some patients present resistance or intolerance with respect to this drug. Anakinra—an IL-1 receptor antagonist—has demonstrated efficacy in colchicine-resistant or -intolerant FMF patients. <i>Background and Objectives:</i> This study aimed to evaluate the clinical characteristics, treatment duration, response to therapy, dose interval modifications, and long-term outcomes in FMF patients treated with anakinra. <i>Materials and Methods:</i> We retrospectively analyzed data from 68 FMF patients who were colchicine-resistant or -intolerant and received anakinra treatment. <i>Results:</i> The median patient age was 40.2 years, with a predominance of female patients (57.3%). The median follow-up duration for patients treated with anakinra was 34.2 months. Anakinra dosing was successfully extended in 30.8% of patients. Eight patients discontinued anakinra due to remission, with a median remission duration of 18.4 months. In a subgroup analysis of 57 patients treated with anakinra for at least 12 months, a significant decrease was observed in Pras scores at 0 months, 3 months, and 12 months, as well as in Erythrocyte Sedimentation Rate, C-reactive protein, and Serum Amyloid A values (all <i>p</i> < 0.001). Statistically significant decreases in 24 h proteinuria values were found between 0 and 3 months, 3 and 12 months, and 0 and 12 months (<i>p</i> = 0.011, <i>p</i> = 0.006, and <i>p</i> = 0.007, respectively). Anakinra use in pregnancy and kidney transplant recipients was well tolerated. Dose extension and treatment discontinuation in remission are feasible strategies. <i>Conclusions:</i> These findings support the use of anakinra as a good treatment option in selected patients. |
| format | Article |
| id | doaj-art-1e8e33932e8d4602b3e9a173e023f2c8 |
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| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-1e8e33932e8d4602b3e9a173e023f2c82025-08-20T01:56:28ZengMDPI AGMedicina1010-660X1648-91442025-04-0161579210.3390/medicina61050792Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life ExperienceTuğba Ocak0Havva Nur Köse1Burcu Yağız2Belkıs Nihan Coşkun3Ediz Dalkılıç4Yavuz Pehlivan5Department of Rheumatology, Bursa City Hospital, 16250 Bursa, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Uludag University, 16285 Bursa, TurkeyDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, TurkeyDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, TurkeyDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, TurkeyDepartment of Rheumatology, Faculty of Medicine, Uludag University, 16285 Bursa, TurkeyFamilial Mediterranean Fever (FMF) is characterized by recurrent febrile attacks and serositis. While colchicine is the primary treatment for FMF, some patients present resistance or intolerance with respect to this drug. Anakinra—an IL-1 receptor antagonist—has demonstrated efficacy in colchicine-resistant or -intolerant FMF patients. <i>Background and Objectives:</i> This study aimed to evaluate the clinical characteristics, treatment duration, response to therapy, dose interval modifications, and long-term outcomes in FMF patients treated with anakinra. <i>Materials and Methods:</i> We retrospectively analyzed data from 68 FMF patients who were colchicine-resistant or -intolerant and received anakinra treatment. <i>Results:</i> The median patient age was 40.2 years, with a predominance of female patients (57.3%). The median follow-up duration for patients treated with anakinra was 34.2 months. Anakinra dosing was successfully extended in 30.8% of patients. Eight patients discontinued anakinra due to remission, with a median remission duration of 18.4 months. In a subgroup analysis of 57 patients treated with anakinra for at least 12 months, a significant decrease was observed in Pras scores at 0 months, 3 months, and 12 months, as well as in Erythrocyte Sedimentation Rate, C-reactive protein, and Serum Amyloid A values (all <i>p</i> < 0.001). Statistically significant decreases in 24 h proteinuria values were found between 0 and 3 months, 3 and 12 months, and 0 and 12 months (<i>p</i> = 0.011, <i>p</i> = 0.006, and <i>p</i> = 0.007, respectively). Anakinra use in pregnancy and kidney transplant recipients was well tolerated. Dose extension and treatment discontinuation in remission are feasible strategies. <i>Conclusions:</i> These findings support the use of anakinra as a good treatment option in selected patients.https://www.mdpi.com/1648-9144/61/5/792anakinracolchicine-intolerantcolchicine-resistantfamilial mediterranean fever |
| spellingShingle | Tuğba Ocak Havva Nur Köse Burcu Yağız Belkıs Nihan Coşkun Ediz Dalkılıç Yavuz Pehlivan Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience Medicina anakinra colchicine-intolerant colchicine-resistant familial mediterranean fever |
| title | Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience |
| title_full | Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience |
| title_fullStr | Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience |
| title_full_unstemmed | Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience |
| title_short | Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience |
| title_sort | efficacy and safety of anakinra in colchicine resistant or intolerant familial mediterranean fever a single center real life experience |
| topic | anakinra colchicine-intolerant colchicine-resistant familial mediterranean fever |
| url | https://www.mdpi.com/1648-9144/61/5/792 |
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