Polysaccharides derived from Rosa rugosa cv. Plena ameliorate colorectal cancer by regulating intestinal microbiota composition and lipid metabolism pathway

Polysaccharides derived from Rosa rugosa cv. Plena ameliorate colorectal cancer by regulating intestinal microbiota composition and lipid metabolism pathway

Abstract This study elucidates the anti-colorectal cancer (CRC) mechanism of Rosa rugosa cv. Plena polysaccharide RPP1 against AOM/DSS-induced carcinogenesis. Purified via water extraction and chromatography, RPP1 was characterized as an eight-monosaccharide polymer by HPLC. In CRC mice, RPP1 admini...

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Main Authors: Chunyu Dai, Xuan Zheng, Jingxin Zhu, Hongxing Zhang, Junhua Jin, Xiaona Pang, Xiangyang Li, Yuanhong Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Science of Food
Online Access:https://doi.org/10.1038/s41538-025-00544-2
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