Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism
Heparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug reaction in which heparin forms complexes with platelet factor 4 forming neoantigens that are recognized by autoantibodies. Antiphospholipid syndrome (APS) is similar to HIT in that it is mediated by autoantibodies that are also...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/3423548 |
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| author | Samuel Adediran Nicole Agostino |
| author_facet | Samuel Adediran Nicole Agostino |
| author_sort | Samuel Adediran |
| collection | DOAJ |
| description | Heparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug reaction in which heparin forms complexes with platelet factor 4 forming neoantigens that are recognized by autoantibodies. Antiphospholipid syndrome (APS) is similar to HIT in that it is mediated by autoantibodies that are also prothrombotic. We present a case of rare coexistence of antiphospholipid antibody syndrome and heparin-induced thrombocytopenia. |
| format | Article |
| id | doaj-art-1e796f2770b14f28acca45d4e3901a1d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-1e796f2770b14f28acca45d4e3901a1d2025-08-20T03:54:57ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/34235483423548Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous ThromboembolismSamuel Adediran0Nicole Agostino1Lehigh Valley Health Network, Departments of Hematology and Oncology and Medicine, Allentown, PA, USALehigh Valley Health Network, Departments of Hematology and Oncology and Medicine, Allentown, PA, USAHeparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug reaction in which heparin forms complexes with platelet factor 4 forming neoantigens that are recognized by autoantibodies. Antiphospholipid syndrome (APS) is similar to HIT in that it is mediated by autoantibodies that are also prothrombotic. We present a case of rare coexistence of antiphospholipid antibody syndrome and heparin-induced thrombocytopenia.http://dx.doi.org/10.1155/2017/3423548 |
| spellingShingle | Samuel Adediran Nicole Agostino Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism Case Reports in Hematology |
| title | Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism |
| title_full | Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism |
| title_fullStr | Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism |
| title_full_unstemmed | Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism |
| title_short | Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism |
| title_sort | coexistence of antiphospholipid syndrome and heparin induced thrombocytopenia in a patient with recurrent venous thromboembolism |
| url | http://dx.doi.org/10.1155/2017/3423548 |
| work_keys_str_mv | AT samueladediran coexistenceofantiphospholipidsyndromeandheparininducedthrombocytopeniainapatientwithrecurrentvenousthromboembolism AT nicoleagostino coexistenceofantiphospholipidsyndromeandheparininducedthrombocytopeniainapatientwithrecurrentvenousthromboembolism |