Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review
IntroductionThere are few reports of severe hematological involvement in children with neonatal lupus erythematosus (NLE) treated with exchange transfusion. In this case report, we present a female patient with NLE admitted to the Children's Hospital of Soochow University. The main clinical man...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1470323/full |
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| author | Minqian Zhou Wenqiang Sun Hanghang Peng Xueping Zhu |
| author_facet | Minqian Zhou Wenqiang Sun Hanghang Peng Xueping Zhu |
| author_sort | Minqian Zhou |
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| description | IntroductionThere are few reports of severe hematological involvement in children with neonatal lupus erythematosus (NLE) treated with exchange transfusion. In this case report, we present a female patient with NLE admitted to the Children's Hospital of Soochow University. The main clinical manifestations were pancytopenia and congenital heart block (CHB). Her condition was serious and could not be improved by conventional treatment; however, she responded well to exchange transfusion therapy.Case presentationA female infant, aged 1 month and 3 days, was admitted to the Children's Hospital of Soochow University owing to the “discovery of thrombocytopenia over 1 month.” She tested positive for anti-SSA IgG, anti-Ro-52 IgG, and anti-mitochondrial M2 antibodies. In contrast, her mother tested positive for ANA (1:320) and anti-Ro/SSA antibodies. The patient was diagnosed with NLE and presented with pancytopenia and CHB. Her cardiac function was normal and no intervention was performed; however, her hematological involvement was more severe, without significant improvement after steroid, intravenous immunoglobulin, and transfusion treatments. After exchange transfusion therapy, the patient significantly improved, and the short-term follow-up prognosis was good.ConclusionFor patients with NLE presenting with hematological involvement that cannot be improved by conventional treatment or whose condition is serious, exchange transfusion therapy should be considered to reduce antibody titers and improve their condition. |
| format | Article |
| id | doaj-art-1e793497da9b477083fdae97675f9d9d |
| institution | OA Journals |
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| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-1e793497da9b477083fdae97675f9d9d2025-08-20T02:11:34ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-10-011210.3389/fped.2024.14703231470323Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature reviewMinqian ZhouWenqiang SunHanghang PengXueping ZhuIntroductionThere are few reports of severe hematological involvement in children with neonatal lupus erythematosus (NLE) treated with exchange transfusion. In this case report, we present a female patient with NLE admitted to the Children's Hospital of Soochow University. The main clinical manifestations were pancytopenia and congenital heart block (CHB). Her condition was serious and could not be improved by conventional treatment; however, she responded well to exchange transfusion therapy.Case presentationA female infant, aged 1 month and 3 days, was admitted to the Children's Hospital of Soochow University owing to the “discovery of thrombocytopenia over 1 month.” She tested positive for anti-SSA IgG, anti-Ro-52 IgG, and anti-mitochondrial M2 antibodies. In contrast, her mother tested positive for ANA (1:320) and anti-Ro/SSA antibodies. The patient was diagnosed with NLE and presented with pancytopenia and CHB. Her cardiac function was normal and no intervention was performed; however, her hematological involvement was more severe, without significant improvement after steroid, intravenous immunoglobulin, and transfusion treatments. After exchange transfusion therapy, the patient significantly improved, and the short-term follow-up prognosis was good.ConclusionFor patients with NLE presenting with hematological involvement that cannot be improved by conventional treatment or whose condition is serious, exchange transfusion therapy should be considered to reduce antibody titers and improve their condition.https://www.frontiersin.org/articles/10.3389/fped.2024.1470323/fullneonatal lupus erythematosuspancytopeniacongenital heart blockexchange transfusioncase report |
| spellingShingle | Minqian Zhou Wenqiang Sun Hanghang Peng Xueping Zhu Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review Frontiers in Pediatrics neonatal lupus erythematosus pancytopenia congenital heart block exchange transfusion case report |
| title | Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review |
| title_full | Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review |
| title_fullStr | Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review |
| title_full_unstemmed | Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review |
| title_short | Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review |
| title_sort | neonatal lupus erythematosus successfully treated by exchange transfusion a case report and literature review |
| topic | neonatal lupus erythematosus pancytopenia congenital heart block exchange transfusion case report |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1470323/full |
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