NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition

NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition

Abstract In the early stage of intracerebral hemorrhage (ICH), rebleeding occurs when blood from the initial hematoma permeates the surrounding brain parenchyma through the disrupted blood–brain barrier (BBB), exacerbating brain injury. Neuroinflammation is a critical driver of the pathological proc...

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Bibliographic Details
Main Authors: Di Hu, Cheng Huang, Ling Tang, Jiawen Lei, Jiaqi Wang, Wenzheng Hu, Minshan Chen, Siyuan Song, Lin Lu, Pingyi Xu
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
NR4A2
Neuroinflammation
Microglial polarization
Blood–brain barrier
TLR4
TRAF6/NF-κB
Online Access:https://doi.org/10.1007/s00018-025-05755-0
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