Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections
ABSTRACT Globally, an estimated 2.1 billion malaria cases and 11.7 million malaria deaths were averted in the period 2000–2022. Noticeably, despite effective control measurements, in 2022 there were an estimated 249 million malaria cases in 85 malaria-endemic countries and an increase of 5 million c...
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| Language: | English |
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American Society for Microbiology
2025-03-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02304-24 |
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| author | Núria Sima Alberto Ayllon-Hermida Carmen Fernández-Becerra Hernando A. del Portillo |
| author_facet | Núria Sima Alberto Ayllon-Hermida Carmen Fernández-Becerra Hernando A. del Portillo |
| author_sort | Núria Sima |
| collection | DOAJ |
| description | ABSTRACT Globally, an estimated 2.1 billion malaria cases and 11.7 million malaria deaths were averted in the period 2000–2022. Noticeably, despite effective control measurements, in 2022 there were an estimated 249 million malaria cases in 85 malaria-endemic countries and an increase of 5 million cases compared with 2021. Further understanding the biology, epidemiology, and pathogenesis of human malaria is therefore essential for achieving malaria elimination. Extracellular vesicles (EVs) are membrane-enclosed nanoparticles pivotal in intercellular communication and secreted by all cell types. Here, we will review what is currently known about EVs in malaria, from biogenesis and cargo to molecular insights of pathophysiology. Of relevance, a meta-analysis of proteomics cargo, and comparisons between in vitro and in vivo human studies revealed striking differences with those few studies reported from patients. Thus, indicating the need for rigor standardization of methodologies and for transitioning to human infections to elucidate their physiological role. We conclude with a focus on translational aspects in diagnosis and vaccine development and highlight key gaps in the knowledge of EVs in malaria research. |
| format | Article |
| id | doaj-art-1e6df952a7d54c499c419b8a88ef81f4 |
| institution | DOAJ |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-1e6df952a7d54c499c419b8a88ef81f42025-08-20T02:53:19ZengAmerican Society for MicrobiologymBio2150-75112025-03-0116310.1128/mbio.02304-24Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infectionsNúria Sima0Alberto Ayllon-Hermida1Carmen Fernández-Becerra2Hernando A. del Portillo3ISGlobal, Barcelona, SpainISGlobal, Barcelona, SpainISGlobal, Barcelona, SpainISGlobal, Barcelona, SpainABSTRACT Globally, an estimated 2.1 billion malaria cases and 11.7 million malaria deaths were averted in the period 2000–2022. Noticeably, despite effective control measurements, in 2022 there were an estimated 249 million malaria cases in 85 malaria-endemic countries and an increase of 5 million cases compared with 2021. Further understanding the biology, epidemiology, and pathogenesis of human malaria is therefore essential for achieving malaria elimination. Extracellular vesicles (EVs) are membrane-enclosed nanoparticles pivotal in intercellular communication and secreted by all cell types. Here, we will review what is currently known about EVs in malaria, from biogenesis and cargo to molecular insights of pathophysiology. Of relevance, a meta-analysis of proteomics cargo, and comparisons between in vitro and in vivo human studies revealed striking differences with those few studies reported from patients. Thus, indicating the need for rigor standardization of methodologies and for transitioning to human infections to elucidate their physiological role. We conclude with a focus on translational aspects in diagnosis and vaccine development and highlight key gaps in the knowledge of EVs in malaria research.https://journals.asm.org/doi/10.1128/mbio.02304-24malariaextracellular vesiclesmolecular cargopathophysiologydiagnosisbiomarkers |
| spellingShingle | Núria Sima Alberto Ayllon-Hermida Carmen Fernández-Becerra Hernando A. del Portillo Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections mBio malaria extracellular vesicles molecular cargo pathophysiology diagnosis biomarkers |
| title | Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections |
| title_full | Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections |
| title_fullStr | Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections |
| title_full_unstemmed | Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections |
| title_short | Extracellular vesicles in malaria: proteomics insights, in vitro and in vivo studies indicate the need for transitioning to natural human infections |
| title_sort | extracellular vesicles in malaria proteomics insights in vitro and in vivo studies indicate the need for transitioning to natural human infections |
| topic | malaria extracellular vesicles molecular cargo pathophysiology diagnosis biomarkers |
| url | https://journals.asm.org/doi/10.1128/mbio.02304-24 |
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