Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

<h4>Background</h4>The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are important goals that are central to the design of an effect...

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Main Authors: Davide Corti, Johannes P M Langedijk, Andreas Hinz, Michael S Seaman, Fabrizia Vanzetta, Blanca M Fernandez-Rodriguez, Chiara Silacci, Debora Pinna, David Jarrossay, Sunita Balla-Jhagjhoorsingh, Betty Willems, Maria J Zekveld, Hanna Dreja, Eithne O'Sullivan, Corinna Pade, Chloe Orkin, Simon A Jeffs, David C Montefiori, David Davis, Winfried Weissenhorn, Aine McKnight, Jonathan L Heeney, Federica Sallusto, Quentin J Sattentau, Robin A Weiss, Antonio Lanzavecchia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008805&type=printable
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