Autoreactive Antibodies Associated with Castleman Disease Triad
The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis obliterans. Here, we describe the Castleman triad in a 19-year-old male with unicentric hyaline vascular type Castleman disease (HV-CD). This pa...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2024/9382107 |
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| author | Jacqueline A. Turner Ali Hakimi Hannah Lee Jeffrey T. Schowinsky Jeffrey M. Sippel Bradford J. Siegele Raul M. Torres William A. Robinson |
| author_facet | Jacqueline A. Turner Ali Hakimi Hannah Lee Jeffrey T. Schowinsky Jeffrey M. Sippel Bradford J. Siegele Raul M. Torres William A. Robinson |
| author_sort | Jacqueline A. Turner |
| collection | DOAJ |
| description | The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis obliterans. Here, we describe the Castleman triad in a 19-year-old male with unicentric hyaline vascular type Castleman disease (HV-CD). This patient presented with an array of positive antibodies, including anti-cyclic citrullinated peptide, anti-double-stranded DNA, and Sjogren’s IgG. Interestingly, the patient’s rheumatologic symptoms resolved after tumor resection, while his antibody profile remained relatively unchanged. HV-CD, with a triad presentation, was thought to be from a paraneoplastic syndrome secondary to an underlying lymphoproliferative disorder. The findings presented here identify multiple autoantibodies potentially contributing to this patient’s presentation with HV-CD. |
| format | Article |
| id | doaj-art-1e69e9c95320442ea9383cccec73152c |
| institution | OA Journals |
| issn | 2090-6617 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-1e69e9c95320442ea9383cccec73152c2025-08-20T02:03:47ZengWileyCase Reports in Immunology2090-66172024-01-01202410.1155/2024/9382107Autoreactive Antibodies Associated with Castleman Disease TriadJacqueline A. Turner0Ali Hakimi1Hannah Lee2Jeffrey T. Schowinsky3Jeffrey M. Sippel4Bradford J. Siegele5Raul M. Torres6William A. Robinson7Division of Medical OncologyUniversity of Colorado Anschutz School of MedicineDivision of Hematology and OncologyDepartment of PathologyDivision of PulmonologyDepartment of PathologyDepartment of Immunology and MicrobiologyDivision of Medical OncologyThe Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis obliterans. Here, we describe the Castleman triad in a 19-year-old male with unicentric hyaline vascular type Castleman disease (HV-CD). This patient presented with an array of positive antibodies, including anti-cyclic citrullinated peptide, anti-double-stranded DNA, and Sjogren’s IgG. Interestingly, the patient’s rheumatologic symptoms resolved after tumor resection, while his antibody profile remained relatively unchanged. HV-CD, with a triad presentation, was thought to be from a paraneoplastic syndrome secondary to an underlying lymphoproliferative disorder. The findings presented here identify multiple autoantibodies potentially contributing to this patient’s presentation with HV-CD.http://dx.doi.org/10.1155/2024/9382107 |
| spellingShingle | Jacqueline A. Turner Ali Hakimi Hannah Lee Jeffrey T. Schowinsky Jeffrey M. Sippel Bradford J. Siegele Raul M. Torres William A. Robinson Autoreactive Antibodies Associated with Castleman Disease Triad Case Reports in Immunology |
| title | Autoreactive Antibodies Associated with Castleman Disease Triad |
| title_full | Autoreactive Antibodies Associated with Castleman Disease Triad |
| title_fullStr | Autoreactive Antibodies Associated with Castleman Disease Triad |
| title_full_unstemmed | Autoreactive Antibodies Associated with Castleman Disease Triad |
| title_short | Autoreactive Antibodies Associated with Castleman Disease Triad |
| title_sort | autoreactive antibodies associated with castleman disease triad |
| url | http://dx.doi.org/10.1155/2024/9382107 |
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