A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis?
Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/128068 |
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| _version_ | 1832556728018796544 |
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| author | Barrie J. Anthony Jeremy T. Allen Yuesheng S. Li Donald P. McManus |
| author_facet | Barrie J. Anthony Jeremy T. Allen Yuesheng S. Li Donald P. McManus |
| author_sort | Barrie J. Anthony |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease. |
| format | Article |
| id | doaj-art-1e6877545e1b4656af194f324519ac19 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-1e6877545e1b4656af194f324519ac192025-02-03T05:44:30ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/128068128068A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis?Barrie J. Anthony0Jeremy T. Allen1Yuesheng S. Li2Donald P. McManus3Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, AustraliaDepartment of Biology, Centre for Parasitology and Disease, Biomedical Sciences Research Institute, University of Salford, Manchester M5 4WT, UKQueensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, AustraliaQueensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, AustraliaPeroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease.http://dx.doi.org/10.1155/2012/128068 |
| spellingShingle | Barrie J. Anthony Jeremy T. Allen Yuesheng S. Li Donald P. McManus A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? PPAR Research |
| title | A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? |
| title_full | A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? |
| title_fullStr | A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? |
| title_full_unstemmed | A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? |
| title_short | A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? |
| title_sort | role for peroxisome proliferator activated receptors in the immunopathology of schistosomiasis |
| url | http://dx.doi.org/10.1155/2012/128068 |
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