Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia

Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia

Abstract Background In the Northern Territory (NT) of Australia, First Nations people with chronic hepatitis B (CHB) are infected with a unique sub-genotype, C4, which contains mutations linked to progressive fibrosis and hepatocellular carcinoma. This cohort study aimed to investigate disease progr...

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Main Authors: Genevieve E. Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y. C. Tong, David Boettiger, Benjamin Cowie, Joshua S. Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies, on behalf of the Hep B PAST Partnership
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Infectious Diseases
Subjects:
Chronic hepatitis B
Liver cirrhosis
First Nations health
Hepatitis B virus
Viral genotype
Online Access:https://doi.org/10.1186/s12879-025-11213-w
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