Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population
Abstract Background The prevalence of type 2 diabetes mellitus (T2DM) remains high and biomarkers related to T2DM are needed to be investigated. This study aimed to investigate the association between neutrophil percentage-to-albumin ratio (NPAR) with all-cause mortality and the risk of cardiovascul...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-024-20924-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571219413565440 |
|---|---|
| author | Geng Shen Yuting Liu Can Zhou Wei Luo Yun-xiao Yang Shuai Guo Jiayi Yi Lin Wang Wei Li Zhao-gong Zhi Xiu-huan Chen Chen Li Yanyan Jin Hai Gao |
| author_facet | Geng Shen Yuting Liu Can Zhou Wei Luo Yun-xiao Yang Shuai Guo Jiayi Yi Lin Wang Wei Li Zhao-gong Zhi Xiu-huan Chen Chen Li Yanyan Jin Hai Gao |
| author_sort | Geng Shen |
| collection | DOAJ |
| description | Abstract Background The prevalence of type 2 diabetes mellitus (T2DM) remains high and biomarkers related to T2DM are needed to be investigated. This study aimed to investigate the association between neutrophil percentage-to-albumin ratio (NPAR) with all-cause mortality and the risk of cardiovascular disease (CVD) mortality in community-dwelling individuals with T2DM. Methods This prospective cohort study included 3602 adults aged 20 or above who were diagnosed with diabetes by the American Diabetes Association criteria in the US National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2016, and followed up until 2019. Multivariable Cox proportional hazards regression models were utilized to determine the relationship between NPAR with all-cause mortality and cardiovascular disease (CVD) mortality. Restricted cubic spline regression analyses were employed to explore the nonlinear relationship between NPAR and cardiovascular disease (CVD) mortality. The assessment of nonlinearity was conducted using the likelihood ratio test. Results After adjustment, the risk ratio for all-cause mortality in the highest NPAR group (≥ 15.40) compared to the lowest serum NPAR reference group (< 13.30) was 1.62 (95% CI, 1.36, 1.94) with P values < 0.001. Nevertheless, the risk ratio for cardiovascular disease (CVD) mortality in the highest NPAR group (≥ 15.40) versus the lowest serum NPAR reference group (< 13.30) was 1.41 (95% CI, 0.99, 2.00) with a P value of 0.06. Among patients with T2DM, serum NPAR levels exhibited a nonlinear correlation with both CVD mortality risk and all-cause mortality risk, with P values < 0.001 for both. Conclusions This study identified a significant association between elevated levels of the neutrophil percentage-to-albumin ratio (NPAR) and an increased risk of all-cause mortality among individuals with type 2 diabetes mellitus (T2DM). Conversely, no correlation was found between NPAR levels and CVD mortality. |
| format | Article |
| id | doaj-art-1e62953447b64fcca83804a189be8322 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-1e62953447b64fcca83804a189be83222025-02-02T12:45:35ZengBMCBMC Public Health1471-24582025-01-0125111110.1186/s12889-024-20924-9Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes populationGeng Shen0Yuting Liu1Can Zhou2Wei Luo3Yun-xiao Yang4Shuai Guo5Jiayi Yi6Lin Wang7Wei Li8Zhao-gong Zhi9Xiu-huan Chen10Chen Li11Yanyan Jin12Hai Gao13Department of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Background The prevalence of type 2 diabetes mellitus (T2DM) remains high and biomarkers related to T2DM are needed to be investigated. This study aimed to investigate the association between neutrophil percentage-to-albumin ratio (NPAR) with all-cause mortality and the risk of cardiovascular disease (CVD) mortality in community-dwelling individuals with T2DM. Methods This prospective cohort study included 3602 adults aged 20 or above who were diagnosed with diabetes by the American Diabetes Association criteria in the US National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2016, and followed up until 2019. Multivariable Cox proportional hazards regression models were utilized to determine the relationship between NPAR with all-cause mortality and cardiovascular disease (CVD) mortality. Restricted cubic spline regression analyses were employed to explore the nonlinear relationship between NPAR and cardiovascular disease (CVD) mortality. The assessment of nonlinearity was conducted using the likelihood ratio test. Results After adjustment, the risk ratio for all-cause mortality in the highest NPAR group (≥ 15.40) compared to the lowest serum NPAR reference group (< 13.30) was 1.62 (95% CI, 1.36, 1.94) with P values < 0.001. Nevertheless, the risk ratio for cardiovascular disease (CVD) mortality in the highest NPAR group (≥ 15.40) versus the lowest serum NPAR reference group (< 13.30) was 1.41 (95% CI, 0.99, 2.00) with a P value of 0.06. Among patients with T2DM, serum NPAR levels exhibited a nonlinear correlation with both CVD mortality risk and all-cause mortality risk, with P values < 0.001 for both. Conclusions This study identified a significant association between elevated levels of the neutrophil percentage-to-albumin ratio (NPAR) and an increased risk of all-cause mortality among individuals with type 2 diabetes mellitus (T2DM). Conversely, no correlation was found between NPAR levels and CVD mortality.https://doi.org/10.1186/s12889-024-20924-9Neutrophil percentage-to-albumin ratio (NPAR)Type 2 diabetes mellitus (T2DM)All-cause mortalityCardiovascular disease (CVD) mortalityNational Health and Nutrition Examination Survey (NHANES)Inflammation |
| spellingShingle | Geng Shen Yuting Liu Can Zhou Wei Luo Yun-xiao Yang Shuai Guo Jiayi Yi Lin Wang Wei Li Zhao-gong Zhi Xiu-huan Chen Chen Li Yanyan Jin Hai Gao Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population BMC Public Health Neutrophil percentage-to-albumin ratio (NPAR) Type 2 diabetes mellitus (T2DM) All-cause mortality Cardiovascular disease (CVD) mortality National Health and Nutrition Examination Survey (NHANES) Inflammation |
| title | Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population |
| title_full | Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population |
| title_fullStr | Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population |
| title_full_unstemmed | Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population |
| title_short | Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population |
| title_sort | associations between neutrophil percentage to albumin ratio level and all cause mortality and cardiovascular disease cause mortality in diabetes population |
| topic | Neutrophil percentage-to-albumin ratio (NPAR) Type 2 diabetes mellitus (T2DM) All-cause mortality Cardiovascular disease (CVD) mortality National Health and Nutrition Examination Survey (NHANES) Inflammation |
| url | https://doi.org/10.1186/s12889-024-20924-9 |
| work_keys_str_mv | AT gengshen associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT yutingliu associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT canzhou associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT weiluo associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT yunxiaoyang associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT shuaiguo associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT jiayiyi associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT linwang associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT weili associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT zhaogongzhi associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT xiuhuanchen associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT chenli associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT yanyanjin associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation AT haigao associationsbetweenneutrophilpercentagetoalbuminratiolevelandallcausemortalityandcardiovasculardiseasecausemortalityindiabetespopulation |