Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L.
This study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2024-03-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2024-0002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573058723872768 |
|---|---|
| author | Zouhri Aziz Bouddine Toufik Menyiy Naoual El El-Mernissi Yahya Laaroussi Hassan Chebaibi Mohamed Amhamdi Hassan Elharrak Abdelhay Nafidi Hiba-Allah Sitotaw Baye Jardan Yousef A. Bin Bourhia Mohammed Hajji Lhoussain |
| author_facet | Zouhri Aziz Bouddine Toufik Menyiy Naoual El El-Mernissi Yahya Laaroussi Hassan Chebaibi Mohamed Amhamdi Hassan Elharrak Abdelhay Nafidi Hiba-Allah Sitotaw Baye Jardan Yousef A. Bin Bourhia Mohammed Hajji Lhoussain |
| author_sort | Zouhri Aziz |
| collection | DOAJ |
| description | This study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents were determined in C. albidus seeds and leaves; antioxidant capacity was assessed by 3 complementary and diverse tests. The carrageenan-induced paw edema technique was used to investigate the anti-inflammatory effect in vivo, and albumin denaturation to evaluate the anti-inflammatory effect in vitro. The acetic acid-induced contortion test, the tail-flick test, and the plantar test were used to assess the analgesic effi cacy in vivo. |
| format | Article |
| id | doaj-art-1e628ab45b964ef997db592bcde35081 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-1e628ab45b964ef997db592bcde350812025-02-02T05:29:03ZengSciendoActa Pharmaceutica1846-95582024-03-01741819910.2478/acph-2024-0002Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L.Zouhri Aziz0Bouddine Toufik1Menyiy Naoual El2El-Mernissi Yahya3Laaroussi Hassan4Chebaibi Mohamed5Amhamdi Hassan6Elharrak Abdelhay7Nafidi Hiba-Allah8Sitotaw Baye9Jardan Yousef A. Bin10Bourhia Mohammed11Hajji Lhoussain12Bioactives and Environmental Health Laboratory Faculty of Sciences, Moulay Ismail University MeknesB.P. 11201, MoroccoBioactives and Environmental Health Laboratory Faculty of Sciences, Moulay Ismail University MeknesB.P. 11201, MoroccoLaboratory of Pharmacology, National Agency for Medicinal and Aromatic Plants, Taounate 34025, MoroccoResearch Unit in Applied Chemistry, Faculty of Science and Techniques, Abdelmalek Essaadi University, Al Hoceima 32003, MoroccoDepartment of Biology, Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah of Fez, 30000, MoroccoLaboratory of Biomedical and Translational Research Faculty of Medicine and Pharmacy of Fez, University of Sidi Mohamed Ben Abdellah, BP 1893, Km 22 Road of Sidi Harazem, Fez, MoroccoResearch Unit in Applied Chemistry, Faculty of Science and Techniques, Abdelmalek Essaadi University, Al Hoceima 32003, MoroccoBioactives and Environmental Health Laboratory Faculty of Sciences, Moulay Ismail University MeknesB.P. 11201, MoroccoDepartment of Food Science, Faculty of Agricultural and Food Sciences, Laval University2325 Quebec City, QC G1V 0A6, CanadaDepartment of Biology, Bahir Dar University Bahir Dar, EthiopiaDepartment of Pharmaceutics, College of Pharmacy King Saud University, Riyadh, Saudi ArabiaHigher Institute of Nursing Professions and Technical Health, Laayoune 70000, MoroccoBioactives and Environmental Health Laboratory Faculty of Sciences, Moulay Ismail University MeknesB.P. 11201, MoroccoThis study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents were determined in C. albidus seeds and leaves; antioxidant capacity was assessed by 3 complementary and diverse tests. The carrageenan-induced paw edema technique was used to investigate the anti-inflammatory effect in vivo, and albumin denaturation to evaluate the anti-inflammatory effect in vitro. The acetic acid-induced contortion test, the tail-flick test, and the plantar test were used to assess the analgesic effi cacy in vivo.https://doi.org/10.2478/acph-2024-0002cistus albidus l.polyphenolsanalgesic activityanti-inflammatoryantioxidant activity |
| spellingShingle | Zouhri Aziz Bouddine Toufik Menyiy Naoual El El-Mernissi Yahya Laaroussi Hassan Chebaibi Mohamed Amhamdi Hassan Elharrak Abdelhay Nafidi Hiba-Allah Sitotaw Baye Jardan Yousef A. Bin Bourhia Mohammed Hajji Lhoussain Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. Acta Pharmaceutica cistus albidus l. polyphenols analgesic activity anti-inflammatory antioxidant activity |
| title | Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. |
| title_full | Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. |
| title_fullStr | Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. |
| title_full_unstemmed | Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. |
| title_short | Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. |
| title_sort | chemical composition and potential antioxidant anti inflammatory and analgesic efficacy of cistus albidus l |
| topic | cistus albidus l. polyphenols analgesic activity anti-inflammatory antioxidant activity |
| url | https://doi.org/10.2478/acph-2024-0002 |
| work_keys_str_mv | AT zouhriaziz chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT bouddinetoufik chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT menyiynaoualel chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT elmernissiyahya chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT laaroussihassan chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT chebaibimohamed chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT amhamdihassan chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT elharrakabdelhay chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT nafidihibaallah chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT sitotawbaye chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT jardanyousefabin chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT bourhiamohammed chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl AT hajjilhoussain chemicalcompositionandpotentialantioxidantantiinflammatoryandanalgesicefficacyofcistusalbidusl |