Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis
Fufang E’jiao Jiang (FEJ) as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood, and it has a positive impact on women’s health. To find out the material basis and mechanism of FEJ, a sys...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-09-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250228 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550163325222912 |
|---|---|
| author | Xiang Li Xiao Xu Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She |
| author_facet | Xiang Li Xiao Xu Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | Fufang E’jiao Jiang (FEJ) as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood, and it has a positive impact on women’s health. To find out the material basis and mechanism of FEJ, a systematic “compound-effect-target” analysis including chemical composition resolution, zebrafish, network pharmacology, molecular docking, transcriptome, and bibliometric analysis was adopted. 124 chemical components including ginsenosides, and phenylethanoid glycosides in FEJ were discovered, and effects of FEJ on promoting the generation of immune cells, erythropoiesis and angiogenesis in zebrafish were exhibited. Based on network pharmacology, molecular docking and in vivo activity assay, 6 compounds including jionoside A1, isoacteoside, echinacoside, acteoside, lobetyolin, and rehmannioside D were identified as active components of FEJ. Transcriptome data showed that several pathways such as complement and coagulation cascades, ECM-receptor interaction, and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ. 19 common targets were obtained through combined analysis of network pharmacology and transcriptomics, and 5 targets of them were verified by PCR. The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism, pathway in cancer, etc., which was consistent with the results of network pharmacology and transcriptome. The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets. |
| format | Article |
| id | doaj-art-1e611765fdce478e83d1e41ab73324e7 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-1e611765fdce478e83d1e41ab73324e72025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011352813283210.26599/FSHW.2022.9250228Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysisXiang Li0Xiao Xu1Ying Dong2Shusheng Fan3Xueyang Ren4Yuan Zheng5Jiamu Ma6Feng Zhang7Qingyue Deng8Xianxian Li9Yingyu He10Mengyu Sun11Wei Liu12Mengxia Li13Qing Xia14Yan Zhang15Gaimei She16School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E-E-Jiao Co., Ltd., Liaocheng 252201, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, ChinaFufang E’jiao Jiang (FEJ) as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood, and it has a positive impact on women’s health. To find out the material basis and mechanism of FEJ, a systematic “compound-effect-target” analysis including chemical composition resolution, zebrafish, network pharmacology, molecular docking, transcriptome, and bibliometric analysis was adopted. 124 chemical components including ginsenosides, and phenylethanoid glycosides in FEJ were discovered, and effects of FEJ on promoting the generation of immune cells, erythropoiesis and angiogenesis in zebrafish were exhibited. Based on network pharmacology, molecular docking and in vivo activity assay, 6 compounds including jionoside A1, isoacteoside, echinacoside, acteoside, lobetyolin, and rehmannioside D were identified as active components of FEJ. Transcriptome data showed that several pathways such as complement and coagulation cascades, ECM-receptor interaction, and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ. 19 common targets were obtained through combined analysis of network pharmacology and transcriptomics, and 5 targets of them were verified by PCR. The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism, pathway in cancer, etc., which was consistent with the results of network pharmacology and transcriptome. The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.https://www.sciopen.com/article/10.26599/FSHW.2022.9250228fufang e’jiao jiangzebrafish (danio rerio)network pharmacologytranscriptomebibliometrics |
| spellingShingle | Xiang Li Xiao Xu Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis Food Science and Human Wellness fufang e’jiao jiang zebrafish (danio rerio) network pharmacology transcriptome bibliometrics |
| title | Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis |
| title_full | Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis |
| title_fullStr | Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis |
| title_full_unstemmed | Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis |
| title_short | Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis |
| title_sort | fufang e jiao jiang s effect on immunity hematopoiesis and angiogenesis via a systematic compound effect target analysis |
| topic | fufang e’jiao jiang zebrafish (danio rerio) network pharmacology transcriptome bibliometrics |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250228 |
| work_keys_str_mv | AT xiangli fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT xiaoxu fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT yingdong fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT shushengfan fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT xueyangren fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT yuanzheng fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT jiamuma fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT fengzhang fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT qingyuedeng fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT xianxianli fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT yingyuhe fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT mengyusun fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT weiliu fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT mengxiali fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT qingxia fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT yanzhang fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis AT gaimeishe fufangejiaojiangseffectonimmunityhematopoiesisandangiogenesisviaasystematiccompoundeffecttargetanalysis |