Beyond tissue: Liquid biopsy's promise in unmasking oral cancer
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy of the oral cavity. It arises from complex interactions between personal lifestyle, genetics, and environmental factors, including tobacco smoking, betel chewing, alcohol consumption, viral infections, and radiation exposure. The high mor...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Oral Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000086 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553725424926720 |
|---|---|
| author | Sakshi Deorah Akanchha Singh Shalini Gupta |
| author_facet | Sakshi Deorah Akanchha Singh Shalini Gupta |
| author_sort | Sakshi Deorah |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is a prevalent malignancy of the oral cavity. It arises from complex interactions between personal lifestyle, genetics, and environmental factors, including tobacco smoking, betel chewing, alcohol consumption, viral infections, and radiation exposure. The high mortality and morbidity rates associated with this disease underscore the need for early detection tools and effective screening strategies.Traditional diagnostic methods, primarily tissue biopsy remain the gold standard for Oral potentially malignant diseases (OPMDs) and OSCC. However, tissue biopsy has limitations such as invasiveness, cost, and inability to capture tumor heterogeneity effectively. To address these challenges, recent research has focused on liquid biopsy, a minimally invasive technique that allows the assessment of tumor-derived components in various biological fluids.A comprehensive search in PubMed, Scopus, and Google Scholar was performed using relevant keywords to structure this review. Only English articles were included and assessed according to titles, abstracts, and full texts. This review delves into blood and salivary biomarkers, including circulating tumor cells (CTCs), cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), exosomes, and microRNA (miRNA), as potential tools for OSCC diagnosis. CtDNA, in particular, represents tumor-derived DNA fragments in the systemic circulation, offering valuable insights into the disease's status. Liquid biopsy, in conjunction with these biomarkers, holds promise as a non-invasive and efficient approach to early OSCC detection, potentially revolutionizing diagnostic methods and improving patient outcomes. |
| format | Article |
| id | doaj-art-1e6022757cfb47e7a0d3997d0c317074 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-1e6022757cfb47e7a0d3997d0c3170742025-01-09T06:15:11ZengElsevierOral Oncology Reports2772-90602024-03-019100162Beyond tissue: Liquid biopsy's promise in unmasking oral cancerSakshi Deorah0Akanchha Singh1Shalini Gupta2Department of Oral Pathology & Microbiology, King George's Medical University, Lucknow, 226003, UP, IndiaDepartment of Oral Pathology & Microbiology, King George's Medical University, Lucknow, 226003, UP, IndiaCorresponding author. Department of Oral Pathology & Microbiology, King George's Medical University, Lucknow, 226003, UP, India.; Department of Oral Pathology & Microbiology, King George's Medical University, Lucknow, 226003, UP, IndiaOral squamous cell carcinoma (OSCC) is a prevalent malignancy of the oral cavity. It arises from complex interactions between personal lifestyle, genetics, and environmental factors, including tobacco smoking, betel chewing, alcohol consumption, viral infections, and radiation exposure. The high mortality and morbidity rates associated with this disease underscore the need for early detection tools and effective screening strategies.Traditional diagnostic methods, primarily tissue biopsy remain the gold standard for Oral potentially malignant diseases (OPMDs) and OSCC. However, tissue biopsy has limitations such as invasiveness, cost, and inability to capture tumor heterogeneity effectively. To address these challenges, recent research has focused on liquid biopsy, a minimally invasive technique that allows the assessment of tumor-derived components in various biological fluids.A comprehensive search in PubMed, Scopus, and Google Scholar was performed using relevant keywords to structure this review. Only English articles were included and assessed according to titles, abstracts, and full texts. This review delves into blood and salivary biomarkers, including circulating tumor cells (CTCs), cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), exosomes, and microRNA (miRNA), as potential tools for OSCC diagnosis. CtDNA, in particular, represents tumor-derived DNA fragments in the systemic circulation, offering valuable insights into the disease's status. Liquid biopsy, in conjunction with these biomarkers, holds promise as a non-invasive and efficient approach to early OSCC detection, potentially revolutionizing diagnostic methods and improving patient outcomes.http://www.sciencedirect.com/science/article/pii/S2772906024000086Oral squamous cell carcinomaLiquid biopsyCirculating tumor cellsCirculating tumor DNAExosomes |
| spellingShingle | Sakshi Deorah Akanchha Singh Shalini Gupta Beyond tissue: Liquid biopsy's promise in unmasking oral cancer Oral Oncology Reports Oral squamous cell carcinoma Liquid biopsy Circulating tumor cells Circulating tumor DNA Exosomes |
| title | Beyond tissue: Liquid biopsy's promise in unmasking oral cancer |
| title_full | Beyond tissue: Liquid biopsy's promise in unmasking oral cancer |
| title_fullStr | Beyond tissue: Liquid biopsy's promise in unmasking oral cancer |
| title_full_unstemmed | Beyond tissue: Liquid biopsy's promise in unmasking oral cancer |
| title_short | Beyond tissue: Liquid biopsy's promise in unmasking oral cancer |
| title_sort | beyond tissue liquid biopsy s promise in unmasking oral cancer |
| topic | Oral squamous cell carcinoma Liquid biopsy Circulating tumor cells Circulating tumor DNA Exosomes |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000086 |
| work_keys_str_mv | AT sakshideorah beyondtissueliquidbiopsyspromiseinunmaskingoralcancer AT akanchhasingh beyondtissueliquidbiopsyspromiseinunmaskingoralcancer AT shalinigupta beyondtissueliquidbiopsyspromiseinunmaskingoralcancer |