Biomarkers for early diagnosis of sepsis-associated acute kidney injury
Sepsis-associated acute kidney injury (SA-AKI) is a heterogeneous syndrome caused by direct mechanisms of sepsis or indirect mechanisms induced by sepsis treatment, leading to kidney damage. Current research of SA-AKI focuses on the application of novel diagnostic biomarkers, including proenkephalin...
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The Editorial Department of Chinese Journal of Clinical Research
2024-11-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241101 |
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| author | GE Xin |
| author_facet | GE Xin |
| author_sort | GE Xin |
| collection | DOAJ |
| description | Sepsis-associated acute kidney injury (SA-AKI) is a heterogeneous syndrome caused by direct mechanisms of sepsis or indirect mechanisms induced by sepsis treatment, leading to kidney damage. Current research of SA-AKI focuses on the application of novel diagnostic biomarkers, including proenkephalin A 119-159, soluble thrombomodulin, hepcidin, urinary angiotensinogen, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, cystatin C, kidney injury molecule-1, liver-type fatty acid-binding protein, and cell cycle arrest proteins. These biomarkers are related to the pathogenesis of SA-AKI. This paper summarizes the biological functions, basic and clinical research status of these early diagnostic markers, and their role in the treatment of critically ill SA-AKI patients, aiming to assist in the early identification, diagnosis, and treatment of SA-AKI in clinical practice.
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| format | Article |
| id | doaj-art-1e5fdc6f132e4436bbcf872a86454e49 |
| institution | OA Journals |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-1e5fdc6f132e4436bbcf872a86454e492025-08-20T01:53:22ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822024-11-0137111649165410.13429/j.cnki.cjcr.2024.11.001Biomarkers for early diagnosis of sepsis-associated acute kidney injuryGE Xin 0Department of Emergency and Critical Care Medicine, Wuxi Ninth Hospital Affiliated to Soochow University, Wuxi, Jiangsu 214062, ChinaSepsis-associated acute kidney injury (SA-AKI) is a heterogeneous syndrome caused by direct mechanisms of sepsis or indirect mechanisms induced by sepsis treatment, leading to kidney damage. Current research of SA-AKI focuses on the application of novel diagnostic biomarkers, including proenkephalin A 119-159, soluble thrombomodulin, hepcidin, urinary angiotensinogen, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, cystatin C, kidney injury molecule-1, liver-type fatty acid-binding protein, and cell cycle arrest proteins. These biomarkers are related to the pathogenesis of SA-AKI. This paper summarizes the biological functions, basic and clinical research status of these early diagnostic markers, and their role in the treatment of critically ill SA-AKI patients, aiming to assist in the early identification, diagnosis, and treatment of SA-AKI in clinical practice. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241101sepsis-associated acute kidney injury， proenkephalin 119-159， soluble thrombomodulin， hepcidin， urinary angiotensinogen， monocyte chemotactic protein-1 |
| spellingShingle | GE Xin Biomarkers for early diagnosis of sepsis-associated acute kidney injury Zhongguo linchuang yanjiu sepsis-associated acute kidney injury， proenkephalin 119-159， soluble thrombomodulin， hepcidin， urinary angiotensinogen， monocyte chemotactic protein-1 |
| title | Biomarkers for early diagnosis of sepsis-associated acute kidney injury |
| title_full | Biomarkers for early diagnosis of sepsis-associated acute kidney injury |
| title_fullStr | Biomarkers for early diagnosis of sepsis-associated acute kidney injury |
| title_full_unstemmed | Biomarkers for early diagnosis of sepsis-associated acute kidney injury |
| title_short | Biomarkers for early diagnosis of sepsis-associated acute kidney injury |
| title_sort | biomarkers for early diagnosis of sepsis associated acute kidney injury |
| topic | sepsis-associated acute kidney injury， proenkephalin 119-159， soluble thrombomodulin， hepcidin， urinary angiotensinogen， monocyte chemotactic protein-1 |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241101 |
| work_keys_str_mv | AT gexin biomarkersforearlydiagnosisofsepsisassociatedacutekidneyinjury |