Biomarkers for early diagnosis of sepsis-associated acute kidney injury
Sepsis-associated acute kidney injury (SA-AKI) is a heterogeneous syndrome caused by direct mechanisms of sepsis or indirect mechanisms induced by sepsis treatment, leading to kidney damage. Current research of SA-AKI focuses on the application of novel diagnostic biomarkers, including proenkephalin...
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| Format: | Article |
| Language: | zho |
| Published: |
The Editorial Department of Chinese Journal of Clinical Research
2024-11-01
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| Series: | Zhongguo linchuang yanjiu |
| Subjects: | |
| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241101 |
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| Summary: | Sepsis-associated acute kidney injury (SA-AKI) is a heterogeneous syndrome caused by direct mechanisms of sepsis or indirect mechanisms induced by sepsis treatment, leading to kidney damage. Current research of SA-AKI focuses on the application of novel diagnostic biomarkers, including proenkephalin A 119-159, soluble thrombomodulin, hepcidin, urinary angiotensinogen, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, cystatin C, kidney injury molecule-1, liver-type fatty acid-binding protein, and cell cycle arrest proteins. These biomarkers are related to the pathogenesis of SA-AKI. This paper summarizes the biological functions, basic and clinical research status of these early diagnostic markers, and their role in the treatment of critically ill SA-AKI patients, aiming to assist in the early identification, diagnosis, and treatment of SA-AKI in clinical practice.
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| ISSN: | 1674-8182 |