CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY
Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that prod...
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Faculty of Medicine, Universitas Diponegoro
2021-03-01
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| Series: | Jurnal Kedokteran Diponegoro |
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| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/29955 |
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| author | Maria Hotmaida Carolina Munthe Novi Kusumaningrum Amallia Nuggetsiana Setyawati Astika Widy Utomo Santoso Santoso |
| author_facet | Maria Hotmaida Carolina Munthe Novi Kusumaningrum Amallia Nuggetsiana Setyawati Astika Widy Utomo Santoso Santoso |
| author_sort | Maria Hotmaida Carolina Munthe |
| collection | DOAJ |
| description | Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation.
Objective: To determine the correlation between serum IL-23 levels and AV severity in men.
Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables.
Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756).
Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men. |
| format | Article |
| id | doaj-art-1e5ea42bf92649a8ab94ecdd2159c43c |
| institution | Kabale University |
| issn | 2540-8844 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Faculty of Medicine, Universitas Diponegoro |
| record_format | Article |
| series | Jurnal Kedokteran Diponegoro |
| spelling | doaj-art-1e5ea42bf92649a8ab94ecdd2159c43c2025-08-20T03:30:24ZengFaculty of Medicine, Universitas DiponegoroJurnal Kedokteran Diponegoro2540-88442021-03-0110215616010.14710/dmj.v10i2.2995525875CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDYMaria Hotmaida Carolina Munthe0Novi Kusumaningrum1Amallia Nuggetsiana Setyawati2Astika Widy Utomo3Santoso Santoso4Faculty of Medicine, Universitas Diponegoro, IndonesiaDepartment of Dermatology and Venereology, Universitas Diponegoro, IndonesiaDepartment of Biochemistry, Universitas Diponegoro, IndonesiaDepartment of Pharmacology and Therapy, Universitas Diponegoro, IndonesiaDepartment of Biochemistry, Universitas Diponegoro, IndonesiaBackground: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation. Objective: To determine the correlation between serum IL-23 levels and AV severity in men. Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables. Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756). Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men.https://ejournal3.undip.ac.id/index.php/medico/article/view/29955acne vulgaris, grade of acne vulgaris severity, interleukin-23 |
| spellingShingle | Maria Hotmaida Carolina Munthe Novi Kusumaningrum Amallia Nuggetsiana Setyawati Astika Widy Utomo Santoso Santoso CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY Jurnal Kedokteran Diponegoro acne vulgaris, grade of acne vulgaris severity, interleukin-23 |
| title | CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY |
| title_full | CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY |
| title_fullStr | CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY |
| title_full_unstemmed | CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY |
| title_short | CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY |
| title_sort | correlation of interleukin 23 serum levels in men with acne vulgaris a preliminary study |
| topic | acne vulgaris, grade of acne vulgaris severity, interleukin-23 |
| url | https://ejournal3.undip.ac.id/index.php/medico/article/view/29955 |
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