Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females
Objectives. The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking. Methods. In a cross-sec...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/9352518 |
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| author | Yijia Shao Liang Luo Zi Ren Jiayi Guo Xingxing Xiao Jiana Huang Haitao Zeng Hong Zhan |
| author_facet | Yijia Shao Liang Luo Zi Ren Jiayi Guo Xingxing Xiao Jiana Huang Haitao Zeng Hong Zhan |
| author_sort | Yijia Shao |
| collection | DOAJ |
| description | Objectives. The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking. Methods. In a cross-sectional study, the number and activity of circulating EPCs and nitric oxide production (NO) as well as flow-mediated vasodilation (FMD) in both premenopausal women and age-matched men with or without cigarette smoking were studied. Results. Compared with age-matched men with or without smoking, the number and function of circulating EPCs as well as NO level in premenopausal women were obviously higher than that in the former and not affected by smoking. The number and function of circulating EPCs as well as NO level in male smokers were shown to be the most strongly inhibited. Furthermore, there was significant correlation between EPC number and activity, plasma NO level, and NO secretion by EPCs and FMD. Conclusions. Estradiol was deemed to play an important role in enhancing the number and activity of EPCs and NO production in premenopausal women even when affected by smoking, which may be the important mechanisms underlying vascular protection of estradiol in premenopausal women, but not in age-matched men. |
| format | Article |
| id | doaj-art-1e5cba5564c945c19d2a304915cf5d92 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-1e5cba5564c945c19d2a304915cf5d922025-02-03T01:05:00ZengWileyCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/93525189352518Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal FemalesYijia Shao0Liang Luo1Zi Ren2Jiayi Guo3Xingxing Xiao4Jiana Huang5Haitao Zeng6Hong Zhan7Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, ChinaDepartment of Critical Care Medicine, The Seventh Affiliated Hospital of Sun Yat-Sen University, ShenZhen, Guangdong 518107, ChinaCenter for Reproductive Medicine, Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510605, ChinaCenter for Reproductive Medicine, Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510605, ChinaCenter for Reproductive Medicine, Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510605, ChinaCenter for Reproductive Medicine, Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510605, ChinaCenter for Reproductive Medicine, Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510605, ChinaDivision of Emergency Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, ChinaObjectives. The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking. Methods. In a cross-sectional study, the number and activity of circulating EPCs and nitric oxide production (NO) as well as flow-mediated vasodilation (FMD) in both premenopausal women and age-matched men with or without cigarette smoking were studied. Results. Compared with age-matched men with or without smoking, the number and function of circulating EPCs as well as NO level in premenopausal women were obviously higher than that in the former and not affected by smoking. The number and function of circulating EPCs as well as NO level in male smokers were shown to be the most strongly inhibited. Furthermore, there was significant correlation between EPC number and activity, plasma NO level, and NO secretion by EPCs and FMD. Conclusions. Estradiol was deemed to play an important role in enhancing the number and activity of EPCs and NO production in premenopausal women even when affected by smoking, which may be the important mechanisms underlying vascular protection of estradiol in premenopausal women, but not in age-matched men.http://dx.doi.org/10.1155/2020/9352518 |
| spellingShingle | Yijia Shao Liang Luo Zi Ren Jiayi Guo Xingxing Xiao Jiana Huang Haitao Zeng Hong Zhan Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females Cardiology Research and Practice |
| title | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
| title_full | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
| title_fullStr | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
| title_full_unstemmed | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
| title_short | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
| title_sort | smoking induced inhibition of number and activity of endothelial progenitor cells and nitric oxide in males were reversed by estradiol in premenopausal females |
| url | http://dx.doi.org/10.1155/2020/9352518 |
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