Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review
Isotretinoin is an oral medication commonly utilized to treat severe acne. It belongs to the class of retinoids and is a synthetic form of vitamin A. Possible changes in bone tissue associated with the systemic administration of Isotretinoin for long periods and in high doses, such as hypercalcemia,...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-07-01
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| Series: | AIMS Bioengineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/bioeng.2024012 |
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| author | Maria Júlia Bento Martins Parreira Bruna Trazzi Pagani Matheus Bento Medeiros Moscatel Daniela Vieira Buchaim Carlos Henrique Bertoni Reis Beatriz Flávia de Moraes Trazzi Acácio Fuziy Rogerio Leone Buchaim |
| author_facet | Maria Júlia Bento Martins Parreira Bruna Trazzi Pagani Matheus Bento Medeiros Moscatel Daniela Vieira Buchaim Carlos Henrique Bertoni Reis Beatriz Flávia de Moraes Trazzi Acácio Fuziy Rogerio Leone Buchaim |
| author_sort | Maria Júlia Bento Martins Parreira |
| collection | DOAJ |
| description | Isotretinoin is an oral medication commonly utilized to treat severe acne. It belongs to the class of retinoids and is a synthetic form of vitamin A. Possible changes in bone tissue associated with the systemic administration of Isotretinoin for long periods and in high doses, such as hypercalcemia, osteopenia, diffuse hyperostosis, or even skeletal deformities, are reported in scientific studies. The objective of this literature review was to analyze the available scientific literature on the systemic administration of Isotretinoin and its effects on bone tissue. To this end, articles that demonstrate effects of Isotretinoin on bone metabolism, bone mineral density, bone formation, and resorption, in addition to possible changes generated in this tissue were considered valid for inclusion in this literature review. The search for articles that fit the premise of this work was carried out in the PubMed/MEDLINE database. In a preliminary search, 85 articles were obtained; after in-depth investigation and checking of the inclusion and exclusion criteria, 21 articles were selected, with 17 articles reporting the effect of systemic administration of Isotretinoin in humans and four articles analyzing the effect generated by this substance systemically administrated in animals, more specifically in rats. After analyzing the selected articles, it was possible to observe several reports on hyperostosis or even changes in the formation of bone structures in human patients. Concerning animals, the largest number of studies addressed the changes caused in the formation or development of bone structures by the systemic administration of Isotretinoin. From the current analyses, and given the wide use of Isotretinoin, it is necessary to know its viability and influence on tissues. Its clinical efficacy seems to overcome any of the skeletal side effects observed; however, more studies are necessary to properly evaluate and prove the effects generated on bone tissues as well as other structures. |
| format | Article |
| id | doaj-art-1e5832df3fd84ee59d4b8fe3b590af23 |
| institution | Kabale University |
| issn | 2375-1495 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Bioengineering |
| spelling | doaj-art-1e5832df3fd84ee59d4b8fe3b590af232025-01-24T01:28:36ZengAIMS PressAIMS Bioengineering2375-14952024-07-0111221224010.3934/bioeng.2024012Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature reviewMaria Júlia Bento Martins Parreira0Bruna Trazzi Pagani1Matheus Bento Medeiros Moscatel2Daniela Vieira Buchaim3Carlos Henrique Bertoni Reis4Beatriz Flávia de Moraes Trazzi5Acácio Fuziy6Rogerio Leone Buchaim7Postgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilPostgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilPostgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilGraduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marilia 17525-902, BrazilDentistry School, University of Marilia (UNIMAR), Marilia 17525-902, BrazilMarília Dental Specialization Center (CEO), Marilia 17516-000, BrazilPostgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilIsotretinoin is an oral medication commonly utilized to treat severe acne. It belongs to the class of retinoids and is a synthetic form of vitamin A. Possible changes in bone tissue associated with the systemic administration of Isotretinoin for long periods and in high doses, such as hypercalcemia, osteopenia, diffuse hyperostosis, or even skeletal deformities, are reported in scientific studies. The objective of this literature review was to analyze the available scientific literature on the systemic administration of Isotretinoin and its effects on bone tissue. To this end, articles that demonstrate effects of Isotretinoin on bone metabolism, bone mineral density, bone formation, and resorption, in addition to possible changes generated in this tissue were considered valid for inclusion in this literature review. The search for articles that fit the premise of this work was carried out in the PubMed/MEDLINE database. In a preliminary search, 85 articles were obtained; after in-depth investigation and checking of the inclusion and exclusion criteria, 21 articles were selected, with 17 articles reporting the effect of systemic administration of Isotretinoin in humans and four articles analyzing the effect generated by this substance systemically administrated in animals, more specifically in rats. After analyzing the selected articles, it was possible to observe several reports on hyperostosis or even changes in the formation of bone structures in human patients. Concerning animals, the largest number of studies addressed the changes caused in the formation or development of bone structures by the systemic administration of Isotretinoin. From the current analyses, and given the wide use of Isotretinoin, it is necessary to know its viability and influence on tissues. Its clinical efficacy seems to overcome any of the skeletal side effects observed; however, more studies are necessary to properly evaluate and prove the effects generated on bone tissues as well as other structures.https://www.aimspress.com/article/doi/10.3934/bioeng.2024012isotretinoinbone repairvitamin abone regenerationretinoidbone defectsbone |
| spellingShingle | Maria Júlia Bento Martins Parreira Bruna Trazzi Pagani Matheus Bento Medeiros Moscatel Daniela Vieira Buchaim Carlos Henrique Bertoni Reis Beatriz Flávia de Moraes Trazzi Acácio Fuziy Rogerio Leone Buchaim Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review AIMS Bioengineering isotretinoin bone repair vitamin a bone regeneration retinoid bone defects bone |
| title | Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review |
| title_full | Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review |
| title_fullStr | Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review |
| title_full_unstemmed | Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review |
| title_short | Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review |
| title_sort | effects of systemic administration of the retinoid isotretinoin on bone tissue a narrative literature review |
| topic | isotretinoin bone repair vitamin a bone regeneration retinoid bone defects bone |
| url | https://www.aimspress.com/article/doi/10.3934/bioeng.2024012 |
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