Polyclonal B cells acquire LCMV antigens in a GP1-dependent manner.

Polyclonal B cells acquire LCMV antigens in a GP1-dependent manner.

The polyclonal, T-dependent nature of hypergammaglobulinemia during murine infection with LCMV is well defined, however the mechanism by which polyclonal B cells acquire antigens for presentation remains unknown. Here we use LCMV-specific CD4 + transgenic T cells to explore several hypotheses for B...

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Bibliographic Details
Main Authors: Gabriel Chamberlain, Guillaume L Lopez, Léa Bourguignon, Xavier Laulhé, Yasmine Adda-Bouchard, Tania Charpentier, Rebekah Honce, Jason W Botten, Alain Lamarre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013345
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https://doi.org/10.1371/journal.ppat.1013345

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