IL-6 as a Mediator of Platelet Hyper-Responsiveness
Interleukin-6 (IL-6) is a pleiotropic cytokine with critical roles in immune regulation, inflammation, and haematopoiesis. While its functions in host defence and tissue repair are well established, accumulating evidence suggests that IL-6 also can directly and indirectly modulate megakaryocyte and...
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MDPI AG
2025-05-01
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| author | Connor Elliot Webb Jordan Vautrinot Ingeborg Hers |
| author_facet | Connor Elliot Webb Jordan Vautrinot Ingeborg Hers |
| author_sort | Connor Elliot Webb |
| collection | DOAJ |
| description | Interleukin-6 (IL-6) is a pleiotropic cytokine with critical roles in immune regulation, inflammation, and haematopoiesis. While its functions in host defence and tissue repair are well established, accumulating evidence suggests that IL-6 also can directly and indirectly modulate megakaryocyte and platelet biology. This review examines the mechanistic basis supporting IL-6-mediated platelet hyper-responsiveness, in addition to its effect on megakaryopoiesis and thrombopoiesis in thromboinflammatory disease states. We discuss how IL-6-mediated trans-signalling may sensitizes platelets to activation, and that this may be exclusive to glycoprotein VI (GPVI) stimulation due to Janus kinase (JAK)–signal transducer 2 crosstalk, in addition to other mechanisms that may contribute to priming platelets. We further highlight clinical evidence linking IL-6 to thrombotic complications in cardiovascular disease and infection (e.g., COVID-19 and sepsis). Given the emerging interest in IL-6-targeting therapies as anti-inflammatory and anti-thrombotic agents, a thorough understanding of how IL-6 can drive platelet responsiveness is crucial. |
| format | Article |
| id | doaj-art-1e4f4997f3a7431aa9e822ca0ca4b82b |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-1e4f4997f3a7431aa9e822ca0ca4b82b2025-08-20T03:11:22ZengMDPI AGCells2073-44092025-05-01141176610.3390/cells14110766IL-6 as a Mediator of Platelet Hyper-ResponsivenessConnor Elliot Webb0Jordan Vautrinot1Ingeborg Hers2School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UKSchool of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UKSchool of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UKInterleukin-6 (IL-6) is a pleiotropic cytokine with critical roles in immune regulation, inflammation, and haematopoiesis. While its functions in host defence and tissue repair are well established, accumulating evidence suggests that IL-6 also can directly and indirectly modulate megakaryocyte and platelet biology. This review examines the mechanistic basis supporting IL-6-mediated platelet hyper-responsiveness, in addition to its effect on megakaryopoiesis and thrombopoiesis in thromboinflammatory disease states. We discuss how IL-6-mediated trans-signalling may sensitizes platelets to activation, and that this may be exclusive to glycoprotein VI (GPVI) stimulation due to Janus kinase (JAK)–signal transducer 2 crosstalk, in addition to other mechanisms that may contribute to priming platelets. We further highlight clinical evidence linking IL-6 to thrombotic complications in cardiovascular disease and infection (e.g., COVID-19 and sepsis). Given the emerging interest in IL-6-targeting therapies as anti-inflammatory and anti-thrombotic agents, a thorough understanding of how IL-6 can drive platelet responsiveness is crucial.https://www.mdpi.com/2073-4409/14/11/766interleukin-6plateletshyper-responsivenessthrombo-inflammationthrombosis |
| spellingShingle | Connor Elliot Webb Jordan Vautrinot Ingeborg Hers IL-6 as a Mediator of Platelet Hyper-Responsiveness Cells interleukin-6 platelets hyper-responsiveness thrombo-inflammation thrombosis |
| title | IL-6 as a Mediator of Platelet Hyper-Responsiveness |
| title_full | IL-6 as a Mediator of Platelet Hyper-Responsiveness |
| title_fullStr | IL-6 as a Mediator of Platelet Hyper-Responsiveness |
| title_full_unstemmed | IL-6 as a Mediator of Platelet Hyper-Responsiveness |
| title_short | IL-6 as a Mediator of Platelet Hyper-Responsiveness |
| title_sort | il 6 as a mediator of platelet hyper responsiveness |
| topic | interleukin-6 platelets hyper-responsiveness thrombo-inflammation thrombosis |
| url | https://www.mdpi.com/2073-4409/14/11/766 |
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