Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4

Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4

Background: Hepatocellular carcinoma (HCC) represents a major malignancy globally, characterized by high malignancy and intricate molecular mechanisms. This study aims to explore the role of the long non-coding RNA (lncRNA) lnc-EST885 in HCC development. Methods: Cell experiments including FISH, wes...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	Translational Oncology
Subjects:	Long non-coding RNAs Hepatocellular carcinoma Metastasis TRAF4 Biomarker
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523324003802
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Investigation of Serum TNF-alpha, TRAF-1, andTRAF-2 in Patients Suffer from Ulcerative Colitis
by: Mayada Noori Iqbal, et al.
Published: (2016-04-01)

Interleukin 17A promotes glycolysis to activate human hepatic stellate cells by mediating the TRAF2/TRAF5/HuR/PFKFB3 axis
by: Tao Jiang, et al.
Published: (2024-11-01)

Mitigating cardiac allograft vasculopathy in a murine model via CD40-TRAF6 blockade and cyclosporin A synergy
by: Yajun Huang, et al.
Published: (2025-07-01)

TRAF2 regulates the progression of pulmonary fibrosis through β-catenin-Snail signaling pathway
by: Zhijie Wan, et al.
Published: (2025-05-01)

Germline loss-of-function variant in the E3 ubiquitin ligase TRAF2 in a young adult patient with medulloblastoma: a case report
by: Josh N. Vo, et al.
Published: (2024-12-01)

Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
by: Xu Zhiyan, et al.
Published: (2025-07-01)

miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke
by: Yao ST, et al.
Published: (2016-12-01)

Artesunate Promotes Bone Remodeling Through TRAF6-Mediated NF-κB Signaling Under Orthodontic Stress in Diabetic Rats
by: Yuxiang Zhan, et al.
Published: (2025-08-01)

Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity
by: Ahmed Rakib, et al.
Published: (2025-02-01)

TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence
by: Yu Chen, et al.
Published: (2025-04-01)

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation
by: Guang Zhao, et al.
Published: (2025-05-01)

Nrf2/Nlrp3 signaling in aging BMSCs: Traf6 intervention as a novel approach to osteoporosis treatment
by: Yajun Li, et al.
Published: (2025-10-01)

Study of TRAF3IP3 for prognosis and immune infiltration in hepatocellular carcinoma
by: Xing Wang, et al.
Published: (2024-12-01)

Effect of gnetol on osteoporotic bone defect mice based on RANKL/RANK/TRAF6 and gut microbiota
by: WEI Yuhang, et al.
Published: (2025-04-01)

MiR‐146a Reduces Inflammation in Experimental Pancreatitis via the TRAF6–NF‐κB Signaling Pathway in Mice
by: Xiaoyu Yang, et al.
Published: (2025-03-01)

MicroRNA-18b-5p Inhibits the Malignant Progression of Prostate Cancer Through Downregulating TRAF5
by: Wang X, et al.
Published: (2025-03-01)

Gingipains disrupt bone homeostasis via dual regulation of osteogenesis and osteoclastogenesis through exosomal miR-146a-5p/TRAF6 signaling
by: Jiachen Dong, et al.
Published: (2025-08-01)

Exosome circ-CBLB promotes M1 macrophage polarization in rheumatoid arthritis through the TLR3/TRAF3 signaling axis
by: Mengyu Zhang, et al.
Published: (2025-07-01)

CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension
by: Lea Strohm, et al.
Published: (2025-03-01)

Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway
by: Yue Dong, et al.
Published: (2025-12-01)

NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition
by: Di Hu, et al.
Published: (2025-06-01)

Bibliometric analysis reveals the research hotspots and trends of nasopharyngeal carcinoma immunotherapy
by: Gang Wang, et al.
Published: (2024-12-01)

Mendelian randomization analysis of gut microbiota-immune cell interactions in malignant neoplasm of nasopharynx
by: Qicong Chen, et al.
Published: (2025-07-01)

HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages
by: Zhou J, et al.
Published: (2025-05-01)

Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response
by: Qian Gou, et al.
Published: (2025-02-01)

Genetic association of toll like receptors and breast cancer: a novel approach toward countering the breast cancer tumor invasiveness and recurrence
by: Avishek Das, et al.
Published: (2025-04-01)

PPARα regulates YAP protein levels and activity by affecting its ubiquitination modification
by: Wenhong Zhou, et al.
Published: (2025-02-01)

Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons
by: Ewa Ocłoń, et al.
Published: (2025-01-01)

Fermented Lentinus edodes extract containing α-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice
by: Xin Hu, et al.
Published: (2024-07-01)

Different Activation of TRAF4 and TRAF6 in Inflammatory Bowel Disease
by: Jun Shen, et al.
Published: (2013-01-01)

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
by: Tsvetana Petrova, et al.
Published: (2022-01-01)

eEF-2K Deficiency Boosts the Virus-Specific Effector CD8<sup>+</sup> T Cell Responses During Viral Infection
by: Liqing Wang, et al.
Published: (2024-12-01)

Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes ( 2024;48:885-900)
by: Junfei Gu, et al.
Published: (2025-01-01)

Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes ( 2024;48:885-900)
by: Yea Eun Kang, et al.
Published: (2025-01-01)

Study on the CHJ01 antitumor activity and mechanism via targeting sphingosine kinase 1 in A549 cells
by: Caiyu Liu, et al.
Published: (2025-12-01)

Network toxicology reveals collaborative mechanism of 4NQO and ethanol in esophageal squamous cell carcinogenesis
by: Jianfeng Yuan, et al.
Published: (2025-09-01)

Neuroprotective effects of Gastrodia elata Blume on promoting M2 microglial polarization by inhibiting JNK/TLR4/T3JAM/NF-κB signaling after transient ischemic stroke in rats
by: Shang-Chih Huang, et al.
Published: (2024-09-01)

AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation
by: Jingyi Wang, et al.
Published: (2025-05-01)

Comprehensive Analysis of the Expression, Prognosis and Function of TRAF Family Proteins  in NSCLC
by: Yixuan WANG, et al.
Published: (2025-03-01)

Antitumor activity of gamma-irradiated Rosa canina L. against lung carcinoma in rat model: a proposed mechanism
by: Omayma A. R. Abo-Zaid, et al.
Published: (2025-02-01)