Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics

Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics

BackgroundAccumulating evidence indicates that elevated polyamine levels are closely linked to tumor initiation and progression. However, the precise role of polyamine metabolism in hepatocellular carcinoma (HCC) remains poorly understood.MethodsWe conducted differential expression analysis on bulk...

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Bibliographic Details
Main Authors:	Yuexi Yu, Huiru Liu, Kaipeng Liu, Meiqi Zhao, Yiyan Zhang, Runci Jiang, Fengmei Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Immunology
Subjects:	hepatocellular carcinoma multi-omics analysis single-cell RNA sequencing polyamine metabolism immune therapy machine learning
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570378/full
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