Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties
This study evaluated the effects of Garcinia gummi-gutta (L.) N.Robson (GG) on polycystic ovary syndrome (PCO)-induced in rats and its anti-obesity properties. Fifteen Wistar rats were divided into three groups: control, 10 mg/kg Aqueous Extract of Garcinia gummi-gutta (AEGG), and 20 mg/kg AEGG. PC...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2025-03-01
|
| Series: | Traditional and Integrative Medicine |
| Subjects: | |
| Online Access: | https://jtim.tums.ac.ir/index.php/jtim/article/view/1680 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849768796018966528 |
|---|---|
| author | Lally Hanna Luke Anusha R Prasanna Bharathi Sainath Binoy Varghese Cheriyan |
| author_facet | Lally Hanna Luke Anusha R Prasanna Bharathi Sainath Binoy Varghese Cheriyan |
| author_sort | Lally Hanna Luke |
| collection | DOAJ |
| description |
This study evaluated the effects of Garcinia gummi-gutta (L.) N.Robson (GG) on polycystic ovary syndrome (PCO)-induced in rats and its anti-obesity properties. Fifteen Wistar rats were divided into three groups: control, 10 mg/kg Aqueous Extract of Garcinia gummi-gutta (AEGG), and 20 mg/kg AEGG. PCO was induced using Letrozole-oestradiol, confirmed by vaginal smear tests and weight gain. AEGG was screened for phenol (125.66±1.07 µg/mL) and flavonoid (102.66 ± 0.38 µg/ml) content, with its highest concentrations at 20 mg/mL. Pancreatic lipase inhibition showed AEGG’s anti-lipase effect (66.24%) at 100 μg/mL, compared to orlistat (98.7%) at 1 μg/ml. Rats received 20 mg/kg of AEGG demonstrated the highest significant reduction in body weight (203.8 g ±1.45 SD) and serum luteinizing hormone (LH) levels (1.24 mIU/mL) compared to the 10 mg/kg group and control group. Anatomical examination showed a normal uterus and reduced ovarian cysts in both AEGG-treated groups compared to the control. AEGG, particularly at 20 mg/kg, significantly reduced body weight, LH levels, and reproductive anatomy in PCO-induced rats, while demonstrating potential anti-obesity effects despite lower lipolytic activity compared to orlistat. The study suggests that AEGG at 20 mg/kg offers benefits in managing PCO and preventing obesity.
|
| format | Article |
| id | doaj-art-1e4a38fe72e94af0aff110098d0fe44a |
| institution | DOAJ |
| issn | 2476-5104 2476-5112 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Traditional and Integrative Medicine |
| spelling | doaj-art-1e4a38fe72e94af0aff110098d0fe44a2025-08-20T03:03:41ZengTehran University of Medical SciencesTraditional and Integrative Medicine2476-51042476-51122025-03-0110110.18502/tim.v10i1.18222Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity PropertiesLally Hanna Luke0Anusha R1Prasanna Bharathi Sainath2Binoy Varghese Cheriyan31Department of Clinical Nutrition, MMM College of Health Sciences, Mogappair, Chennai, Tamil Nadu, 6000107, IndiaDepartment of Clinical Nutrition, MMM College of Health Sciences, Mogappair, Chennai, Tamil Nadu, 6000107, IndiaDepartment of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, 602105, IndiaDepartment of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India This study evaluated the effects of Garcinia gummi-gutta (L.) N.Robson (GG) on polycystic ovary syndrome (PCO)-induced in rats and its anti-obesity properties. Fifteen Wistar rats were divided into three groups: control, 10 mg/kg Aqueous Extract of Garcinia gummi-gutta (AEGG), and 20 mg/kg AEGG. PCO was induced using Letrozole-oestradiol, confirmed by vaginal smear tests and weight gain. AEGG was screened for phenol (125.66±1.07 µg/mL) and flavonoid (102.66 ± 0.38 µg/ml) content, with its highest concentrations at 20 mg/mL. Pancreatic lipase inhibition showed AEGG’s anti-lipase effect (66.24%) at 100 μg/mL, compared to orlistat (98.7%) at 1 μg/ml. Rats received 20 mg/kg of AEGG demonstrated the highest significant reduction in body weight (203.8 g ±1.45 SD) and serum luteinizing hormone (LH) levels (1.24 mIU/mL) compared to the 10 mg/kg group and control group. Anatomical examination showed a normal uterus and reduced ovarian cysts in both AEGG-treated groups compared to the control. AEGG, particularly at 20 mg/kg, significantly reduced body weight, LH levels, and reproductive anatomy in PCO-induced rats, while demonstrating potential anti-obesity effects despite lower lipolytic activity compared to orlistat. The study suggests that AEGG at 20 mg/kg offers benefits in managing PCO and preventing obesity. https://jtim.tums.ac.ir/index.php/jtim/article/view/1680Garcinia cambogiaPolycystic ovarian diseaseObesityLuteinizing hormoneUterusOvary |
| spellingShingle | Lally Hanna Luke Anusha R Prasanna Bharathi Sainath Binoy Varghese Cheriyan Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties Traditional and Integrative Medicine Garcinia cambogia Polycystic ovarian disease Obesity Luteinizing hormone Uterus Ovary |
| title | Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties |
| title_full | Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties |
| title_fullStr | Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties |
| title_full_unstemmed | Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties |
| title_short | Garcinia gummi-gutta's Effect on Polycystic Ovary Syndrome-Induced in Rats and Its Anti-Obesity Properties |
| title_sort | garcinia gummi gutta s effect on polycystic ovary syndrome induced in rats and its anti obesity properties |
| topic | Garcinia cambogia Polycystic ovarian disease Obesity Luteinizing hormone Uterus Ovary |
| url | https://jtim.tums.ac.ir/index.php/jtim/article/view/1680 |
| work_keys_str_mv | AT lallyhannaluke garciniagummiguttaseffectonpolycysticovarysyndromeinducedinratsanditsantiobesityproperties AT anushar garciniagummiguttaseffectonpolycysticovarysyndromeinducedinratsanditsantiobesityproperties AT prasannabharathisainath garciniagummiguttaseffectonpolycysticovarysyndromeinducedinratsanditsantiobesityproperties AT binoyvarghesecheriyan garciniagummiguttaseffectonpolycysticovarysyndromeinducedinratsanditsantiobesityproperties |