NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS
Nanocrystal technology enables the production of solid drug particles with a particle size below 1000 nm without the need for any carrier system. By reducing the size of the particles of drugs with low solubility in water, increasing the surface area and decreasing the thickness of the diffusion lay...
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Istanbul University Press
2022-02-01
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| Series: | Sabiad |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/5FF902076E98432C9EFF5F85BA6DE0AA |
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| author | Yağmur Pirinçci Tok Sevgi Güngör Yıldız Özsoy Erginer |
| author_facet | Yağmur Pirinçci Tok Sevgi Güngör Yıldız Özsoy Erginer |
| author_sort | Yağmur Pirinçci Tok |
| collection | DOAJ |
| description | Nanocrystal technology enables the production of solid drug particles with a particle size below 1000 nm without the need for any carrier system. By reducing the size of the particles of drugs with low solubility in water, increasing the surface area and decreasing the thickness of the diffusion layer leads to an increase in k the solubility rate. Accordingly, the increasing concentration gradient in the absorption zone promotes permeation and absorption by passive diffusion between the intestinal lumen and blood. Therefore, it is very important to improve and / or increase their bioavailability by using the nanocrystal technology approach for drug molecules belonging to BCS Class II and IV. Top-down and bottom-up methods are used to obtain nanometer-sized drug particles. In the pharmaceutical industry, top-down methods, which are subdivided into wet milling (BWM) and high pressure homogenization (HPH), are preferred in the ball mill because of its ease of application, repeatability and scalability. With nanocrystal technology, it is aimed to create new dosage forms by providing less side effects, lower doses and faster onset of action of drug molecules that are already approved in the pharmaceutical industry. It is also aimed that new drug molecules can be formulated with better bioavailability. |
| format | Article |
| id | doaj-art-1e4825b2e2374025ba2a0fa073d2bad8 |
| institution | Kabale University |
| issn | 2651-4060 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Sabiad |
| spelling | doaj-art-1e4825b2e2374025ba2a0fa073d2bad82025-08-20T03:53:07ZengIstanbul University PressSabiad2651-40602022-02-0151627010.26650/JARHS2021-808337123456NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGSYağmur Pirinçci Tok0https://orcid.org/0000-0001-6915-0283Sevgi Güngör1https://orcid.org/0000-0002-8199-3010Yıldız Özsoy Erginer2https://orcid.org/0000-0002-9110-3704İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeNanocrystal technology enables the production of solid drug particles with a particle size below 1000 nm without the need for any carrier system. By reducing the size of the particles of drugs with low solubility in water, increasing the surface area and decreasing the thickness of the diffusion layer leads to an increase in k the solubility rate. Accordingly, the increasing concentration gradient in the absorption zone promotes permeation and absorption by passive diffusion between the intestinal lumen and blood. Therefore, it is very important to improve and / or increase their bioavailability by using the nanocrystal technology approach for drug molecules belonging to BCS Class II and IV. Top-down and bottom-up methods are used to obtain nanometer-sized drug particles. In the pharmaceutical industry, top-down methods, which are subdivided into wet milling (BWM) and high pressure homogenization (HPH), are preferred in the ball mill because of its ease of application, repeatability and scalability. With nanocrystal technology, it is aimed to create new dosage forms by providing less side effects, lower doses and faster onset of action of drug molecules that are already approved in the pharmaceutical industry. It is also aimed that new drug molecules can be formulated with better bioavailability.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/5FF902076E98432C9EFF5F85BA6DE0AAnanocrystal technologywater-soluble drugsoral routemethods of preparation |
| spellingShingle | Yağmur Pirinçci Tok Sevgi Güngör Yıldız Özsoy Erginer NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS Sabiad nanocrystal technology water-soluble drugs oral route methods of preparation |
| title | NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS |
| title_full | NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS |
| title_fullStr | NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS |
| title_full_unstemmed | NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS |
| title_short | NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS |
| title_sort | nanocrystal technology increasing oral bioavailability of low soluble drugs |
| topic | nanocrystal technology water-soluble drugs oral route methods of preparation |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/5FF902076E98432C9EFF5F85BA6DE0AA |
| work_keys_str_mv | AT yagmurpirinccitok nanocrystaltechnologyincreasingoralbioavailabilityoflowsolubledrugs AT sevgigungor nanocrystaltechnologyincreasingoralbioavailabilityoflowsolubledrugs AT yıldızozsoyerginer nanocrystaltechnologyincreasingoralbioavailabilityoflowsolubledrugs |