New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction
Atrial fibrillation (AF) and chronic kidney disease (CKD) are common and interrelated diseases, the combination of which is associated with a poor prognosis. The efficacy and safety of direct oral anticoagulants (DOACs) used to prevent thromboembolic complications of AF may depend on renal function...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2020-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4175 |
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| author | Zh. D. Kobalava P. V. Lazarev M. V. Vatsik |
| author_facet | Zh. D. Kobalava P. V. Lazarev M. V. Vatsik |
| author_sort | Zh. D. Kobalava |
| collection | DOAJ |
| description | Atrial fibrillation (AF) and chronic kidney disease (CKD) are common and interrelated diseases, the combination of which is associated with a poor prognosis. The efficacy and safety of direct oral anticoagulants (DOACs) used to prevent thromboembolic complications of AF may depend on renal function due to the specific pharmacokinetics of these drugs. This review considers current data on the role of kidneys in the pathogenesis of ischemic and bleeding events, methods of renal function assessment and related classification issues, as well as comparison of warfarin and DOAC therapy, in patients with AF and renal dysfunction of different stages based on the results of randomized controlled trials and actual clinical practice. DOAC use in the context of dynamic deterioration of renal function, supranormal renal function, and their effect on renal outcomes is discussed. International guidelines on anticoagulant therapy in AF and renal dysfunction were analyzed. |
| format | Article |
| id | doaj-art-1e46f277a86b4289a2d207a2a85362a2 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-1e46f277a86b4289a2d207a2a85362a22025-08-20T03:20:55Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-12-01251110.15829/29/1560-4071-2020-41753098New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunctionZh. D. Kobalava0P. V. Lazarev1M. V. Vatsik2Peoples' Friendship University of RussiaPeoples' Friendship University of RussiaV.V. Vinogradov City Clinical HospitalAtrial fibrillation (AF) and chronic kidney disease (CKD) are common and interrelated diseases, the combination of which is associated with a poor prognosis. The efficacy and safety of direct oral anticoagulants (DOACs) used to prevent thromboembolic complications of AF may depend on renal function due to the specific pharmacokinetics of these drugs. This review considers current data on the role of kidneys in the pathogenesis of ischemic and bleeding events, methods of renal function assessment and related classification issues, as well as comparison of warfarin and DOAC therapy, in patients with AF and renal dysfunction of different stages based on the results of randomized controlled trials and actual clinical practice. DOAC use in the context of dynamic deterioration of renal function, supranormal renal function, and their effect on renal outcomes is discussed. International guidelines on anticoagulant therapy in AF and renal dysfunction were analyzed.https://russjcardiol.elpub.ru/jour/article/view/4175atrial fibrillationchronic kidney diseaseanticoagulantshemodialysispharmacokinetics |
| spellingShingle | Zh. D. Kobalava P. V. Lazarev M. V. Vatsik New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction Российский кардиологический журнал atrial fibrillation chronic kidney disease anticoagulants hemodialysis pharmacokinetics |
| title | New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction |
| title_full | New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction |
| title_fullStr | New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction |
| title_full_unstemmed | New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction |
| title_short | New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction |
| title_sort | new aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction |
| topic | atrial fibrillation chronic kidney disease anticoagulants hemodialysis pharmacokinetics |
| url | https://russjcardiol.elpub.ru/jour/article/view/4175 |
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