Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging
Abstract The purpose of this study was to identify characteristic morphological features of large choroidal blood vessels (pachyvessels) in eyes with central serous chorioretinopathy (CSC) using enhanced depth imaging (EDI) optical coherence tomography (OCT). A total of 116 eyes from 58 patients wit...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12718-9 |
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| author | Mingui Kong So Young Han Yun-Mi Song Sung Yong Park Don-Il Ham |
| author_facet | Mingui Kong So Young Han Yun-Mi Song Sung Yong Park Don-Il Ham |
| author_sort | Mingui Kong |
| collection | DOAJ |
| description | Abstract The purpose of this study was to identify characteristic morphological features of large choroidal blood vessels (pachyvessels) in eyes with central serous chorioretinopathy (CSC) using enhanced depth imaging (EDI) optical coherence tomography (OCT). A total of 116 eyes from 58 patients with CSC and 116 eyes from 58 age- and gender-matched healthy subjects were included. EDI OCT raster scan images were analyzed for the presence of characteristic features of pachyvessels and accompanying retinal pigment epithelial (RPE) abnormalities, with additional imaging data obtained from fluorescein angiography (FA) and indocyanine green angiography (ICGA). Severely dilated pachyvessels abutting the RPE-Bruch’s membrane-choriocapillaris complex, referred to as the “Hanging Drop (HD) sign,” were identified in all acute CSC eyes and 86.4% of CSC eyes overall. The HD sign was observed either with (“active”) or without (“inactive”) vascular wall hyperreflectivity along the RPE-Bruch’s membrane-choriocapillaris complex. The active HD sign was present exclusively in CSC eyes (56.1%) and was significantly more frequent in acute CSC compared to chronic and resolved CSC (88.9%, 47.4%, and 17.6%, respectively; P < 0.05). While the inactive HD sign was also more common in CSC eyes than in unaffected fellow eyes and healthy eyes (77.3%, 30.0%, and 9.5%, respectively), its prevalence did not differ significantly among CSC eyes with varying clinical conditions (P > 0.05). RPE abnormalities were consistently observed in OCT images showing the active HD sign. These findings suggest that characteristic morphological features of pachyvessels discerned using EDI OCT raster scans can aid in the diagnosis and evaluation of CSC. |
| format | Article |
| id | doaj-art-1e425ef2b1e74fcdbb1cd4ee928d7259 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-1e425ef2b1e74fcdbb1cd4ee928d72592025-08-20T04:02:46ZengNature PortfolioScientific Reports2045-23222025-07-0115111610.1038/s41598-025-12718-9Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imagingMingui Kong0So Young Han1Yun-Mi Song2Sung Yong Park3Don-Il Ham4Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Family Medicine, Center for Clinical Research, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of MedicineYesung Jung Eye ClinicDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract The purpose of this study was to identify characteristic morphological features of large choroidal blood vessels (pachyvessels) in eyes with central serous chorioretinopathy (CSC) using enhanced depth imaging (EDI) optical coherence tomography (OCT). A total of 116 eyes from 58 patients with CSC and 116 eyes from 58 age- and gender-matched healthy subjects were included. EDI OCT raster scan images were analyzed for the presence of characteristic features of pachyvessels and accompanying retinal pigment epithelial (RPE) abnormalities, with additional imaging data obtained from fluorescein angiography (FA) and indocyanine green angiography (ICGA). Severely dilated pachyvessels abutting the RPE-Bruch’s membrane-choriocapillaris complex, referred to as the “Hanging Drop (HD) sign,” were identified in all acute CSC eyes and 86.4% of CSC eyes overall. The HD sign was observed either with (“active”) or without (“inactive”) vascular wall hyperreflectivity along the RPE-Bruch’s membrane-choriocapillaris complex. The active HD sign was present exclusively in CSC eyes (56.1%) and was significantly more frequent in acute CSC compared to chronic and resolved CSC (88.9%, 47.4%, and 17.6%, respectively; P < 0.05). While the inactive HD sign was also more common in CSC eyes than in unaffected fellow eyes and healthy eyes (77.3%, 30.0%, and 9.5%, respectively), its prevalence did not differ significantly among CSC eyes with varying clinical conditions (P > 0.05). RPE abnormalities were consistently observed in OCT images showing the active HD sign. These findings suggest that characteristic morphological features of pachyvessels discerned using EDI OCT raster scans can aid in the diagnosis and evaluation of CSC.https://doi.org/10.1038/s41598-025-12718-9CSCPachychoroidPachyvesselsRPEBruch’s membrane |
| spellingShingle | Mingui Kong So Young Han Yun-Mi Song Sung Yong Park Don-Il Ham Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging Scientific Reports CSC Pachychoroid Pachyvessels RPE Bruch’s membrane |
| title | Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging |
| title_full | Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging |
| title_fullStr | Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging |
| title_full_unstemmed | Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging |
| title_short | Comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging |
| title_sort | comprehensive analysis of pachyvessel morphology in central serous chorioretinopathy using multimodal imaging |
| topic | CSC Pachychoroid Pachyvessels RPE Bruch’s membrane |
| url | https://doi.org/10.1038/s41598-025-12718-9 |
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