Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges
Abstract Bone regeneration is integral to maintaining bone function and integrity in the body, as well as treating bone diseases, such as osteoporosis and defects. However, oxidative stress often poses a significant obstacle during bone regeneration, leading to cell damage, inflammatory responses, a...
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BMC
2025-04-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-025-01370-z |
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| author | Hui Li Zhenhe Zhang Jing Liu Huiwen Wang |
| author_facet | Hui Li Zhenhe Zhang Jing Liu Huiwen Wang |
| author_sort | Hui Li |
| collection | DOAJ |
| description | Abstract Bone regeneration is integral to maintaining bone function and integrity in the body, as well as treating bone diseases, such as osteoporosis and defects. However, oxidative stress often poses a significant obstacle during bone regeneration, leading to cell damage, inflammatory responses, and subsequent impediment of normal bone tissue formation. Therefore, to maintain bone regeneration, antioxidant therapy is essential. Bone scaffolds, serving as a temporary support for bone tissue, can provide an ideal microenvironment for cell proliferation and differentiation, effectively promoting bone tissue formation. In recent years, with in-depth research on antioxidants and their mechanisms of action, the development and application of antioxidant bone scaffolds have shown tremendous potential. These antioxidant bone scaffolds not only promote osteogenic differentiation and angiogenesis, but also effectively inhibit the inflammatory response and osteoclast formation, significantly improving the efficiency of bone regeneration. Notably, with the rapid development of nanotechnology, nanozymes with multi-enzyme-like activities have been successfully constructed and encapsulated within bone scaffolds, leading to the proposal of multifunctional antioxidant strategies. Therefore, this review summarizes recent research progress, categorically introducing types of bone scaffolds and antioxidants, elucidating therapeutic strategies of antioxidant bone scaffolds, and identifying current challenges, aiming to provide valuable guidance for subsequent research. |
| format | Article |
| id | doaj-art-1e3bba8a223f4248bb3ccab2ab56efef |
| institution | DOAJ |
| issn | 1475-925X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj-art-1e3bba8a223f4248bb3ccab2ab56efef2025-08-20T03:06:55ZengBMCBioMedical Engineering OnLine1475-925X2025-04-0124112410.1186/s12938-025-01370-zAntioxidant scaffolds for enhanced bone regeneration: recent advances and challengesHui Li0Zhenhe Zhang1Jing Liu2Huiwen Wang3Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Bone regeneration is integral to maintaining bone function and integrity in the body, as well as treating bone diseases, such as osteoporosis and defects. However, oxidative stress often poses a significant obstacle during bone regeneration, leading to cell damage, inflammatory responses, and subsequent impediment of normal bone tissue formation. Therefore, to maintain bone regeneration, antioxidant therapy is essential. Bone scaffolds, serving as a temporary support for bone tissue, can provide an ideal microenvironment for cell proliferation and differentiation, effectively promoting bone tissue formation. In recent years, with in-depth research on antioxidants and their mechanisms of action, the development and application of antioxidant bone scaffolds have shown tremendous potential. These antioxidant bone scaffolds not only promote osteogenic differentiation and angiogenesis, but also effectively inhibit the inflammatory response and osteoclast formation, significantly improving the efficiency of bone regeneration. Notably, with the rapid development of nanotechnology, nanozymes with multi-enzyme-like activities have been successfully constructed and encapsulated within bone scaffolds, leading to the proposal of multifunctional antioxidant strategies. Therefore, this review summarizes recent research progress, categorically introducing types of bone scaffolds and antioxidants, elucidating therapeutic strategies of antioxidant bone scaffolds, and identifying current challenges, aiming to provide valuable guidance for subsequent research.https://doi.org/10.1186/s12938-025-01370-zBone tissue engineeringOxidative stressAntioxidant strategySmart bone scaffoldNanozyme |
| spellingShingle | Hui Li Zhenhe Zhang Jing Liu Huiwen Wang Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges BioMedical Engineering OnLine Bone tissue engineering Oxidative stress Antioxidant strategy Smart bone scaffold Nanozyme |
| title | Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges |
| title_full | Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges |
| title_fullStr | Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges |
| title_full_unstemmed | Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges |
| title_short | Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges |
| title_sort | antioxidant scaffolds for enhanced bone regeneration recent advances and challenges |
| topic | Bone tissue engineering Oxidative stress Antioxidant strategy Smart bone scaffold Nanozyme |
| url | https://doi.org/10.1186/s12938-025-01370-z |
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