Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer
Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. CSCs are thought to be responsible for cancer...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/6012810 |
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| _version_ | 1832552828219949056 |
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| author | Jiangang Zhao Jiahui Li Hans A. Schlößer Felix Popp Marie Christine Popp Hakan Alakus Karl-Walter Jauch Christiane J. Bruns Yue Zhao |
| author_facet | Jiangang Zhao Jiahui Li Hans A. Schlößer Felix Popp Marie Christine Popp Hakan Alakus Karl-Walter Jauch Christiane J. Bruns Yue Zhao |
| author_sort | Jiangang Zhao |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer. In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer. |
| format | Article |
| id | doaj-art-1e346ff386af45659a12c30b1be36fcc |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1e346ff386af45659a12c30b1be36fcc2025-02-03T05:57:40ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/60128106012810Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic CancerJiangang Zhao0Jiahui Li1Hans A. Schlößer2Felix Popp3Marie Christine Popp4Hakan Alakus5Karl-Walter Jauch6Christiane J. Bruns7Yue Zhao8Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral und Vascular Surgery, Ludwig-Maximilian-University (LMU), Munich, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, GermanyCancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer. In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.http://dx.doi.org/10.1155/2017/6012810 |
| spellingShingle | Jiangang Zhao Jiahui Li Hans A. Schlößer Felix Popp Marie Christine Popp Hakan Alakus Karl-Walter Jauch Christiane J. Bruns Yue Zhao Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer Stem Cells International |
| title | Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer |
| title_full | Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer |
| title_fullStr | Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer |
| title_full_unstemmed | Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer |
| title_short | Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer |
| title_sort | targeting cancer stem cells and their niche current therapeutic implications and challenges in pancreatic cancer |
| url | http://dx.doi.org/10.1155/2017/6012810 |
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