Mechanisms of DBS: from informational lesions to circuit modulation and implications in OCD

Mechanisms of DBS: from informational lesions to circuit modulation and implications in OCD

In 2009, treatment-resistant obsessive compulsive disorder (OCD) was approved as an indication for deep brain stimulation (DBS) under a Humanitarian Device Exemption (HDE). This review examines the mechanisms by which DBS produces its effects, focusing on its interaction with the pathophysiology of...

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Bibliographic Details
Main Authors: Julia M. Shea, Chaim M. Feigen, Emad N. Eskandar, Nathaniel J. Killian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Human Neuroscience
Subjects:
obsessive-compulsive disorder
psychosurgery
deep brain stimulation
CSTC circuitry
neuromodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnhum.2025.1492744/full
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