A microRNA signature that correlates with cognition and is a target against cognitive decline
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causa...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2021-10-01
|
| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.202013659 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761521676058624 |
|---|---|
| author | Md Rezaul Islam Lalit Kaurani Tea Berulava Urs Heilbronner Monika Budde Tonatiuh Pena Centeno Vakthang Elerdashvili Maria‐Patapia Zafieriou Eva Benito Sinem M Sertel Maria Goldberg Fanny Senner Janos L Kalman Susanne Burkhardt Anne Sophie Oepen Mohammad Sadman Sakib Cemil Kerimoglu Oliver Wirths Heike Bickeböller Claudia Bartels Frederic Brosseron Katharina Buerger Nicoleta‐Carmen Cosma Klaus Fliessbach Michael T. Heneka Daniel Janowitz Ingo Kilimann Luca Kleinedam Christoph Laske Coraline D Metzger Matthias H Munk Robert Perneczky Oliver Peters Josef Priller Boris S. Rauchmann Nina Roy Anja Schneider Annika Spottke Eike J Spruth Stefan Teipel Maike Tscheuschler Michael Wagner Jens Wiltfang Emrah Düzel Frank Jessen Delcode Study Group Silvio O Rizzoli Wolfram‐Hubertus Zimmermann Thomas G Schulze Peter Falkai Farahnaz Sananbenesi Andre Fischer |
| author_facet | Md Rezaul Islam Lalit Kaurani Tea Berulava Urs Heilbronner Monika Budde Tonatiuh Pena Centeno Vakthang Elerdashvili Maria‐Patapia Zafieriou Eva Benito Sinem M Sertel Maria Goldberg Fanny Senner Janos L Kalman Susanne Burkhardt Anne Sophie Oepen Mohammad Sadman Sakib Cemil Kerimoglu Oliver Wirths Heike Bickeböller Claudia Bartels Frederic Brosseron Katharina Buerger Nicoleta‐Carmen Cosma Klaus Fliessbach Michael T. Heneka Daniel Janowitz Ingo Kilimann Luca Kleinedam Christoph Laske Coraline D Metzger Matthias H Munk Robert Perneczky Oliver Peters Josef Priller Boris S. Rauchmann Nina Roy Anja Schneider Annika Spottke Eike J Spruth Stefan Teipel Maike Tscheuschler Michael Wagner Jens Wiltfang Emrah Düzel Frank Jessen Delcode Study Group Silvio O Rizzoli Wolfram‐Hubertus Zimmermann Thomas G Schulze Peter Falkai Farahnaz Sananbenesi Andre Fischer |
| author_sort | Md Rezaul Islam |
| collection | DOAJ |
| description | Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics. |
| format | Article |
| id | doaj-art-1e2ab5f4a61e40db8cbade9a85f5dc94 |
| institution | DOAJ |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-1e2ab5f4a61e40db8cbade9a85f5dc942025-08-20T03:06:00ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-10-01131112810.15252/emmm.202013659A microRNA signature that correlates with cognition and is a target against cognitive declineMd Rezaul Islam0Lalit Kaurani1Tea Berulava2Urs Heilbronner3Monika Budde4Tonatiuh Pena Centeno5Vakthang Elerdashvili6Maria‐Patapia Zafieriou7Eva Benito8Sinem M Sertel9Maria Goldberg10Fanny Senner11Janos L Kalman12Susanne Burkhardt13Anne Sophie Oepen14Mohammad Sadman Sakib15Cemil Kerimoglu16Oliver Wirths17Heike Bickeböller18Claudia Bartels19Frederic Brosseron20Katharina Buerger21Nicoleta‐Carmen Cosma22Klaus Fliessbach23Michael T. Heneka24Daniel Janowitz25Ingo Kilimann26Luca Kleinedam27Christoph Laske28Coraline D Metzger29Matthias H Munk30Robert Perneczky31Oliver Peters32Josef Priller33Boris S. Rauchmann34Nina Roy35Anja Schneider36Annika Spottke37Eike J Spruth38Stefan Teipel39Maike Tscheuschler40Michael Wagner41Jens Wiltfang42Emrah Düzel43Frank Jessen44Delcode Study GroupSilvio O Rizzoli45Wolfram‐Hubertus Zimmermann46Thomas G Schulze47Peter Falkai48Farahnaz Sananbenesi49Andre Fischer50Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University MunichInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University MunichDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesInstitute of Pharmacology and Toxicology, University Medical Center GöttingenDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment of Neuro‐ and Sensory Physiology, University Medical Center GöttingenDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University MunichInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig‐Maximilians‐University MunichDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesDepartment for Psychiatry and Psychotherapy, University Medical Center GöttingenDepartment of Genetic Epidemiology, University Medical Center GöttingenDepartment for Psychiatry and Psychotherapy, University Medical Center GöttingenGerman Center for Neurodegenerative DiseasesGerman Center for Neurodegenerative Diseases (DZNE, Munich)Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin BerlinGerman Center for Neurodegenerative DiseasesGerman Center for Neurodegenerative DiseasesInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichGerman Center for Neurodegenerative Diseases (DZNE)German Center for Neurodegenerative DiseasesDepartment of Psychosomatic Medicine, Rostock University Medical CenterGerman Center for Neurodegenerative Diseases (DZNE)Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of TübingenDepartment of Psychiatry and Psychotherapy, Ludwig‐Maximilians‐University MunichDepartment of Psychiatry and Psychotherapy, Charité – Universitätsmedizin BerlinGerman Center for Neurodegenerative Diseases (DZNE)Department of Psychiatry and Psychotherapy, Ludwig‐Maximilians‐University MunichGerman Center for Neurodegenerative DiseasesGerman Center for Neurodegenerative DiseasesGerman Center for Neurodegenerative DiseasesGerman Center for Neurodegenerative Diseases (DZNE)German Center for Neurodegenerative Diseases (DZNE)Department of Psychiatry, Medical Faculty, University of CologneGerman Center for Neurodegenerative DiseasesDepartment for Psychiatry and Psychotherapy, University Medical Center GöttingenGerman Center for Neurodegenerative Diseases (DZNE)German Center for Neurodegenerative DiseasesDepartment of Neuro‐ and Sensory Physiology, University Medical Center GöttingenInstitute of Pharmacology and Toxicology, University Medical Center GöttingenDepartment for Psychiatry and Psychotherapy, University Medical Center GöttingenDepartment of Psychiatry and Psychotherapy, Ludwig‐Maximilians‐University MunichDepartment for Psychiatry and Psychotherapy, University Medical Center GöttingenDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative DiseasesAbstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics.https://doi.org/10.15252/emmm.202013659Alzheimerbiomarkercognitive impairmentmicroRNARNA therapeutics |
| spellingShingle | Md Rezaul Islam Lalit Kaurani Tea Berulava Urs Heilbronner Monika Budde Tonatiuh Pena Centeno Vakthang Elerdashvili Maria‐Patapia Zafieriou Eva Benito Sinem M Sertel Maria Goldberg Fanny Senner Janos L Kalman Susanne Burkhardt Anne Sophie Oepen Mohammad Sadman Sakib Cemil Kerimoglu Oliver Wirths Heike Bickeböller Claudia Bartels Frederic Brosseron Katharina Buerger Nicoleta‐Carmen Cosma Klaus Fliessbach Michael T. Heneka Daniel Janowitz Ingo Kilimann Luca Kleinedam Christoph Laske Coraline D Metzger Matthias H Munk Robert Perneczky Oliver Peters Josef Priller Boris S. Rauchmann Nina Roy Anja Schneider Annika Spottke Eike J Spruth Stefan Teipel Maike Tscheuschler Michael Wagner Jens Wiltfang Emrah Düzel Frank Jessen Delcode Study Group Silvio O Rizzoli Wolfram‐Hubertus Zimmermann Thomas G Schulze Peter Falkai Farahnaz Sananbenesi Andre Fischer A microRNA signature that correlates with cognition and is a target against cognitive decline EMBO Molecular Medicine Alzheimer biomarker cognitive impairment microRNA RNA therapeutics |
| title | A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_full | A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_fullStr | A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_full_unstemmed | A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_short | A microRNA signature that correlates with cognition and is a target against cognitive decline |
| title_sort | microrna signature that correlates with cognition and is a target against cognitive decline |
| topic | Alzheimer biomarker cognitive impairment microRNA RNA therapeutics |
| url | https://doi.org/10.15252/emmm.202013659 |
| work_keys_str_mv | AT mdrezaulislam amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT lalitkaurani amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT teaberulava amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT ursheilbronner amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT monikabudde amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT tonatiuhpenacenteno amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT vakthangelerdashvili amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mariapatapiazafieriou amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT evabenito amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT sinemmsertel amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mariagoldberg amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT fannysenner amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT janoslkalman amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT susanneburkhardt amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT annesophieoepen amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mohammadsadmansakib amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT cemilkerimoglu amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT oliverwirths amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT heikebickeboller amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT claudiabartels amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT fredericbrosseron amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT katharinabuerger amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT nicoletacarmencosma amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT klausfliessbach amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT michaeltheneka amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT danieljanowitz amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT ingokilimann amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT lucakleinedam amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT christophlaske amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT coralinedmetzger amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT matthiashmunk amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT robertperneczky amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT oliverpeters amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT josefpriller amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT borissrauchmann amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT ninaroy amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT anjaschneider amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT annikaspottke amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT eikejspruth amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT stefanteipel amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT maiketscheuschler amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT michaelwagner amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT jenswiltfang amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT emrahduzel amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT frankjessen amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT delcodestudygroup amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT silvioorizzoli amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT wolframhubertuszimmermann amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT thomasgschulze amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT peterfalkai amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT farahnazsananbenesi amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT andrefischer amicrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mdrezaulislam micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT lalitkaurani micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT teaberulava micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT ursheilbronner micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT monikabudde micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT tonatiuhpenacenteno micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT vakthangelerdashvili micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mariapatapiazafieriou micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT evabenito micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT sinemmsertel micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mariagoldberg micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT fannysenner micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT janoslkalman micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT susanneburkhardt micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT annesophieoepen micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT mohammadsadmansakib micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT cemilkerimoglu micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT oliverwirths micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT heikebickeboller micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT claudiabartels micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT fredericbrosseron micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT katharinabuerger micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT nicoletacarmencosma micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT klausfliessbach micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT michaeltheneka micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT danieljanowitz micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT ingokilimann micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT lucakleinedam micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT christophlaske micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT coralinedmetzger micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT matthiashmunk micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT robertperneczky micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT oliverpeters micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT josefpriller micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT borissrauchmann micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT ninaroy micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT anjaschneider micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT annikaspottke micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT eikejspruth micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT stefanteipel micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT maiketscheuschler micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT michaelwagner micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT jenswiltfang micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT emrahduzel micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT frankjessen micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT delcodestudygroup micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT silvioorizzoli micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT wolframhubertuszimmermann micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT thomasgschulze micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT peterfalkai micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT farahnazsananbenesi micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline AT andrefischer micrornasignaturethatcorrelateswithcognitionandisatargetagainstcognitivedecline |