Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent
Background. Serum ferritin predicts the onset of diabetes; however, this relationship is not clear amongst South Asians, a population susceptible to glucose intolerance and anaemia. Objective. This study tests whether ferritin levels reflect glucose tolerance in South Asians, independent of lifestyl...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/924387 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850230765831323648 |
|---|---|
| author | Elizabeth A. Hughes Jeetesh V. Patel Zosia Bredow Paramjit S. Gill Julia Chackathayil Elif S. Agaoglu Paul Flinders Rebecca Mirrielees |
| author_facet | Elizabeth A. Hughes Jeetesh V. Patel Zosia Bredow Paramjit S. Gill Julia Chackathayil Elif S. Agaoglu Paul Flinders Rebecca Mirrielees |
| author_sort | Elizabeth A. Hughes |
| collection | DOAJ |
| description | Background. Serum ferritin predicts the onset of diabetes; however, this relationship is not clear amongst South Asians, a population susceptible to glucose intolerance and anaemia. Objective. This study tests whether ferritin levels reflect glucose tolerance in South Asians, independent of lifestyle exposures associated with Indian or British residence. Methods. We randomly sampled 227 Gujaratis in Britain (49.8 (14.4) years, 50% men) and 277 contemporaries living in Gujarati villages (47.6 (11.8) years, 41% men). Both groups underwent a 75 g oral-glucose-tolerance test. We evaluated lifestyle parameters with standardised questionnaires and conducted comprehensive clinical and lab measurements. Results. Across sites, the age-adjusted prevalence of diabetes was 9.8%. Serum ferritin was higher amongst diabetics (P=0.005), irrespective of site, gender, and central obesity (P≤0.02), and was associated with fasting and postchallenge glucose, anthropometry, blood pressure, triglycerides, and nonesterified fatty acids (P<0.001). Diabetes was less in those with low ferritin (<20 mg/mL), P<0.008, and risk estimate = 0.35 (95% CI 0.15–0.81), as were blood pressure and metabolic risk factors. On multivariate analysis, diabetes was independently associated with ferritin (P=0.001) and age (P<0.001). Conclusion. Ferritin levels are positively associated with glucose intolerance in our test groups, independent of gender and Indian or UK lifestyle factors. |
| format | Article |
| id | doaj-art-1e24cac855a145d383695e9c4bebf431 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1e24cac855a145d383695e9c4bebf4312025-08-20T02:03:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/924387924387Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian SubcontinentElizabeth A. Hughes0Jeetesh V. Patel1Zosia Bredow2Paramjit S. Gill3Julia Chackathayil4Elif S. Agaoglu5Paul Flinders6Rebecca Mirrielees7University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands B18 7QH, UKUniversity of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands B18 7QH, UKMedical School, University of Nottingham, Nottingham NG7 2UH, UKPrimary Care Clinical Sciences, University of Birmingham, West Midlands B15 2TT, UKPrimary Care Clinical Sciences, University of Birmingham, West Midlands B15 2TT, UKMedical School, University of Nottingham, Nottingham NG7 2UH, UKMedical School, University of Nottingham, Nottingham NG7 2UH, UKMedical School, University of Nottingham, Nottingham NG7 2UH, UKBackground. Serum ferritin predicts the onset of diabetes; however, this relationship is not clear amongst South Asians, a population susceptible to glucose intolerance and anaemia. Objective. This study tests whether ferritin levels reflect glucose tolerance in South Asians, independent of lifestyle exposures associated with Indian or British residence. Methods. We randomly sampled 227 Gujaratis in Britain (49.8 (14.4) years, 50% men) and 277 contemporaries living in Gujarati villages (47.6 (11.8) years, 41% men). Both groups underwent a 75 g oral-glucose-tolerance test. We evaluated lifestyle parameters with standardised questionnaires and conducted comprehensive clinical and lab measurements. Results. Across sites, the age-adjusted prevalence of diabetes was 9.8%. Serum ferritin was higher amongst diabetics (P=0.005), irrespective of site, gender, and central obesity (P≤0.02), and was associated with fasting and postchallenge glucose, anthropometry, blood pressure, triglycerides, and nonesterified fatty acids (P<0.001). Diabetes was less in those with low ferritin (<20 mg/mL), P<0.008, and risk estimate = 0.35 (95% CI 0.15–0.81), as were blood pressure and metabolic risk factors. On multivariate analysis, diabetes was independently associated with ferritin (P=0.001) and age (P<0.001). Conclusion. Ferritin levels are positively associated with glucose intolerance in our test groups, independent of gender and Indian or UK lifestyle factors.http://dx.doi.org/10.1155/2015/924387 |
| spellingShingle | Elizabeth A. Hughes Jeetesh V. Patel Zosia Bredow Paramjit S. Gill Julia Chackathayil Elif S. Agaoglu Paul Flinders Rebecca Mirrielees Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent International Journal of Endocrinology |
| title | Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent |
| title_full | Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent |
| title_fullStr | Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent |
| title_full_unstemmed | Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent |
| title_short | Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent |
| title_sort | ferritin as a risk factor for glucose intolerance amongst men and women originating from the indian subcontinent |
| url | http://dx.doi.org/10.1155/2015/924387 |
| work_keys_str_mv | AT elizabethahughes ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT jeeteshvpatel ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT zosiabredow ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT paramjitsgill ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT juliachackathayil ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT elifsagaoglu ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT paulflinders ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent AT rebeccamirrielees ferritinasariskfactorforglucoseintoleranceamongstmenandwomenoriginatingfromtheindiansubcontinent |