Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens
Platelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological “slip-bonds” to the boundary of function...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Platelets |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09537104.2024.2353582 |
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| author | Scott J. Denardo Pavlos P. Vlachos Brett A. Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E. Tcheng |
| author_facet | Scott J. Denardo Pavlos P. Vlachos Brett A. Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E. Tcheng |
| author_sort | Scott J. Denardo |
| collection | DOAJ |
| description | Platelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological “slip-bonds” to the boundary of functional gliding without contact. As a result, there is diminished engagement of the coagulation cascade by platelets at these surfaces. Comprehending platelet slip would more precisely direct antithrombotic regimens for different shear environments, including for percutaneous coronary intervention (PCI). In this brief report we promote translation of the proof-of-concept for platelet slip into improved antithrombotic regimens by: (1) reviewing new supporting basic biological science and clinical research for platelet slip; (2) hypothesizing the principal variables that affect platelet slip; (3) applying the consequent construct model in support of-and in some cases to challenge-relevant contemporary guidelines and their foundations (including for urgent, higher-risk PCI); and (4) suggesting future research pathways (both basic and clinical). Should future research demonstrate, explain and control platelet slip, then a paradigm shift for choosing and recommending antithrombotic regimens based on predicted shear rate should follow. Improved clinical outcomes with decreased complications accompanying this paradigm shift for higher-risk PCI would also result in substantive cost savings. |
| format | Article |
| id | doaj-art-1e2368798ccb4e3e9ca86a32e1635a19 |
| institution | OA Journals |
| issn | 0953-7104 1369-1635 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj-art-1e2368798ccb4e3e9ca86a32e1635a192025-08-20T02:27:11ZengTaylor & Francis GroupPlatelets0953-71041369-16352024-12-0135110.1080/09537104.2024.2353582Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimensScott J. Denardo0Pavlos P. Vlachos1Brett A. Meyers2Reza Babakhani-Galangashi3Lin Wang4Zejin Gao5James E. Tcheng6Medicine/Cardiology, Duke University Medical Center, Durham, NC, USASchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USASchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USASchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USADepartment of Statistics, Purdue University, West Lafayette, IN, USADepartment of Statistics, Purdue University, West Lafayette, IN, USAMedicine/Cardiology, Duke University Medical Center, Durham, NC, USAPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological “slip-bonds” to the boundary of functional gliding without contact. As a result, there is diminished engagement of the coagulation cascade by platelets at these surfaces. Comprehending platelet slip would more precisely direct antithrombotic regimens for different shear environments, including for percutaneous coronary intervention (PCI). In this brief report we promote translation of the proof-of-concept for platelet slip into improved antithrombotic regimens by: (1) reviewing new supporting basic biological science and clinical research for platelet slip; (2) hypothesizing the principal variables that affect platelet slip; (3) applying the consequent construct model in support of-and in some cases to challenge-relevant contemporary guidelines and their foundations (including for urgent, higher-risk PCI); and (4) suggesting future research pathways (both basic and clinical). Should future research demonstrate, explain and control platelet slip, then a paradigm shift for choosing and recommending antithrombotic regimens based on predicted shear rate should follow. Improved clinical outcomes with decreased complications accompanying this paradigm shift for higher-risk PCI would also result in substantive cost savings.https://www.tandfonline.com/doi/10.1080/09537104.2024.2353582Cardiovascularplatelet adhesivenessshear strengthslip-bondthrombosis |
| spellingShingle | Scott J. Denardo Pavlos P. Vlachos Brett A. Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E. Tcheng Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens Platelets Cardiovascular platelet adhesiveness shear strength slip-bond thrombosis |
| title | Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens |
| title_full | Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens |
| title_fullStr | Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens |
| title_full_unstemmed | Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens |
| title_short | Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens |
| title_sort | translating proof of concept for platelet slip into improved antithrombotic therapeutic regimens |
| topic | Cardiovascular platelet adhesiveness shear strength slip-bond thrombosis |
| url | https://www.tandfonline.com/doi/10.1080/09537104.2024.2353582 |
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