A Central Role for Troponin C Amino-Terminal α-Helix in Vertebrate Thin Filament Ca<sup>2+</sup>-Activation

A Central Role for Troponin C Amino-Terminal α-Helix in Vertebrate Thin Filament Ca<sup>2+</sup>-Activation

Troponin C (TnC) is the Ca<sup>2+</sup>-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of vertebrate TnC is mainly co...

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Bibliographic Details
Main Authors: Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Physchem
Subjects:
troponin C (TnC)
N-terminal α-helix
thin filament activation
cryo-electron microscopy (cryo-EM)
cardiomyopathy
Online Access:https://www.mdpi.com/2673-7167/5/2/16
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