Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside
Helicobacter pylori, a spiral-shaped Gram-negative bacterium, has been classified as a class I carcinogen by the World Health Organization and recognized as the causative agent for peptic ulcers, duodenal ulcer, gastritis, mucosa-associated lymphoid tissue lymphomas, and gastric cancer. Owing to the...
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| Language: | English |
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Elsevier
2014-09-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422014000249 |
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| author | Malliga Raman Murali Sangeetha Vasudevaraj Naveen Chang Gue Son Hanumantha Rao Balaji Raghavendran |
| author_facet | Malliga Raman Murali Sangeetha Vasudevaraj Naveen Chang Gue Son Hanumantha Rao Balaji Raghavendran |
| author_sort | Malliga Raman Murali |
| collection | DOAJ |
| description | Helicobacter pylori, a spiral-shaped Gram-negative bacterium, has been classified as a class I carcinogen by the World Health Organization and recognized as the causative agent for peptic ulcers, duodenal ulcer, gastritis, mucosa-associated lymphoid tissue lymphomas, and gastric cancer. Owing to their alarming rate of drug resistance, eradication of H. pylori remains a global challenge. Triple therapy consisting of a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole, is generally the recommended standard for the treatment of H. pylori infection. Complementary and alternative medicines have a long history in the treatment of gastrointestinal ailments and various compounds has been tested for anti-H. pylori activity both in vitro and in vivo; however, their successful use in human clinical trials is sporadic. Hence, the aim of this review is to analyze the role of some well-known natural products that have been tested in clinical trials in preventing, altering, or treating H. pylori infections. Whereas some in vitro and in vivo studies in the literature have demonstrated the successful use of a few potential natural products for the treatment of H. pylori-related infections, others indicate a need to consider natural products, with or without triple therapy, as a useful alternative in treating H. pylori-related infections. Thus, the reported mechanisms include killing of H. pylori urease inhibition, induction of bacterial cell damage, and immunomodulatory effect on the host immune system. Furthermore, both in vitro and in vivo studies have demonstrated the successful use of some potential natural products for the treatment of H. pylori-related infections. Nevertheless, the routine prescription of potential complementary and alternative medicines continues to be restrained, and evidence on the safety and efficacy of the active compounds remains a subject of ongoing debate. |
| format | Article |
| id | doaj-art-1e20faabae284e05b72aab9f9b6b0e31 |
| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-1e20faabae284e05b72aab9f9b6b0e312025-08-20T02:03:46ZengElsevierIntegrative Medicine Research2213-42202014-09-013311111810.1016/j.imr.2014.04.001Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedsideMalliga Raman Murali0Sangeetha Vasudevaraj Naveen1Chang Gue Son2Hanumantha Rao Balaji Raghavendran3Tissue Engineering Group, National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), Department of Orthopaedic surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaTissue Engineering Group, National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), Department of Orthopaedic surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaLiver and Immunology Research Center, Oriental Medical College of Daejeon University, Daejeon, South KoreaTissue Engineering Group, National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), Department of Orthopaedic surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaHelicobacter pylori, a spiral-shaped Gram-negative bacterium, has been classified as a class I carcinogen by the World Health Organization and recognized as the causative agent for peptic ulcers, duodenal ulcer, gastritis, mucosa-associated lymphoid tissue lymphomas, and gastric cancer. Owing to their alarming rate of drug resistance, eradication of H. pylori remains a global challenge. Triple therapy consisting of a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole, is generally the recommended standard for the treatment of H. pylori infection. Complementary and alternative medicines have a long history in the treatment of gastrointestinal ailments and various compounds has been tested for anti-H. pylori activity both in vitro and in vivo; however, their successful use in human clinical trials is sporadic. Hence, the aim of this review is to analyze the role of some well-known natural products that have been tested in clinical trials in preventing, altering, or treating H. pylori infections. Whereas some in vitro and in vivo studies in the literature have demonstrated the successful use of a few potential natural products for the treatment of H. pylori-related infections, others indicate a need to consider natural products, with or without triple therapy, as a useful alternative in treating H. pylori-related infections. Thus, the reported mechanisms include killing of H. pylori urease inhibition, induction of bacterial cell damage, and immunomodulatory effect on the host immune system. Furthermore, both in vitro and in vivo studies have demonstrated the successful use of some potential natural products for the treatment of H. pylori-related infections. Nevertheless, the routine prescription of potential complementary and alternative medicines continues to be restrained, and evidence on the safety and efficacy of the active compounds remains a subject of ongoing debate.http://www.sciencedirect.com/science/article/pii/S2213422014000249clinical trialcomplimentary medicineGram-negative bacteriumHelicobacter pylorinatural products |
| spellingShingle | Malliga Raman Murali Sangeetha Vasudevaraj Naveen Chang Gue Son Hanumantha Rao Balaji Raghavendran Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside Integrative Medicine Research clinical trial complimentary medicine Gram-negative bacterium Helicobacter pylori natural products |
| title | Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside |
| title_full | Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside |
| title_fullStr | Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside |
| title_full_unstemmed | Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside |
| title_short | Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside |
| title_sort | current knowledge on alleviating helicobacter pylori infections through the use of some commonly known natural products bench to bedside |
| topic | clinical trial complimentary medicine Gram-negative bacterium Helicobacter pylori natural products |
| url | http://www.sciencedirect.com/science/article/pii/S2213422014000249 |
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