4-1BB Antibodies in Oncology Clinical Trials: A Review

4-1BB Antibodies in Oncology Clinical Trials: A Review

4-1BB is a transmembrane glycoprotein found on T lymphocytes, and signaling through 4-1BB activates and differentiates CD3+ and CD8+ T cells. The ability of 4-1BB to stimulate cytotoxic T-cell responses makes it a promising target for therapeutic cancer immunotherapy development. 4-1BB antibodies ha...

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Bibliographic Details
Main Authors: Robin Schwartz, Keerti Vajrala, Gerald S. Falchook
Format: Article
Language:English
Published: Innovative Healthcare Institute 2025-03-01
Series:Journal of Immunotherapy and Precision Oncology
Subjects:
4-1bb
cd137
clinical trial
immunotherapy
Online Access:https://jipo.org/doi/pdf/10.36401/JIPO-24-30
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Summary:4-1BB is a transmembrane glycoprotein found on T lymphocytes, and signaling through 4-1BB activates and differentiates CD3+ and CD8+ T cells. The ability of 4-1BB to stimulate cytotoxic T-cell responses makes it a promising target for therapeutic cancer immunotherapy development. 4-1BB antibodies have shown promising antitumor activity in preclinical studies and clinical trials. Common side effects include transaminase elevation, cytopenias, fatigue, and nausea. This clinical review summarizes past and current 4-1BB antibodies in oncology clinical trials.
ISSN:2666-2345
2590-017X

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