Application of amniotic membrane in osteoarthritis management
Introduction: Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by articular cartilage degradation, inflammation, and pain. The current treatment options for OA are limited in their ability to provide long-term relief and restore joint function. However, recent advances in...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Cartilage & Joint Preservation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254524000106 |
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| author | Zuzana Macečková Jiří Pergner Martin Krbec Milan Urban Michal Zahradníček |
| author_facet | Zuzana Macečková Jiří Pergner Martin Krbec Milan Urban Michal Zahradníček |
| author_sort | Zuzana Macečková |
| collection | DOAJ |
| description | Introduction: Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by articular cartilage degradation, inflammation, and pain. The current treatment options for OA are limited in their ability to provide long-term relief and restore joint function. However, recent advances in regenerative medicine have led to the exploration of alternative therapeutic strategies, including the application of amniotic membrane (AM) in OA management. AM has emerged as a promising therapeutic option due to its unique properties and regenerative potential, although the mechanism of action of AM in OA is not fully elucidated. Objectives: Here, we discuss the anti-inflammatory, immunomodulatory, and regenerative properties of AM that make it an attractive candidate for OA treatment. Preclinical studies utilizing animal models have demonstrated the ability of AM to promote cartilage repair, reduce inflammation, and improve joint function. Clinical trials evaluating the safety and efficacy of AM-based therapies in OA patients have also shown promising results, with improvements in pain relief and functional outcomes. Conclusions: In conclusion, while AM shows promise for OA management, additional studies and clinical trials are necessary to fully understand its therapeutic potential and establish it as a safe and effective treatment option for individuals with OA. |
| format | Article |
| id | doaj-art-1e0a080ac7d349c38853c37bdad1dd27 |
| institution | DOAJ |
| issn | 2667-2545 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj-art-1e0a080ac7d349c38853c37bdad1dd272025-08-20T03:02:07ZengElsevierJournal of Cartilage & Joint Preservation2667-25452025-03-015110017410.1016/j.jcjp.2024.100174Application of amniotic membrane in osteoarthritis managementZuzana Macečková0Jiří Pergner1Martin Krbec2Milan Urban3Michal Zahradníček4PrimeCell Bioscience, A.S., Ostrava, Czech Republic; Zuzana Macečková, PrimeCell Bioscience, A.S., Dr. Slabihoudka 11, 708 00 Ostrava, Czech Republic.PrimeCell Bioscience, A.S., Ostrava, Czech Republic; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech RepublicDepartment of Orthopaedics and Traumatology, 3rd Faculty of Medicine Charles University, Prague, Czech RepublicDepartment of Orthopaedics and Traumatology, 3rd Faculty of Medicine Charles University, Prague, Czech RepublicPrimeCell Bioscience, A.S., Ostrava, Czech RepublicIntroduction: Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by articular cartilage degradation, inflammation, and pain. The current treatment options for OA are limited in their ability to provide long-term relief and restore joint function. However, recent advances in regenerative medicine have led to the exploration of alternative therapeutic strategies, including the application of amniotic membrane (AM) in OA management. AM has emerged as a promising therapeutic option due to its unique properties and regenerative potential, although the mechanism of action of AM in OA is not fully elucidated. Objectives: Here, we discuss the anti-inflammatory, immunomodulatory, and regenerative properties of AM that make it an attractive candidate for OA treatment. Preclinical studies utilizing animal models have demonstrated the ability of AM to promote cartilage repair, reduce inflammation, and improve joint function. Clinical trials evaluating the safety and efficacy of AM-based therapies in OA patients have also shown promising results, with improvements in pain relief and functional outcomes. Conclusions: In conclusion, while AM shows promise for OA management, additional studies and clinical trials are necessary to fully understand its therapeutic potential and establish it as a safe and effective treatment option for individuals with OA.http://www.sciencedirect.com/science/article/pii/S2667254524000106Amniotic membraneClinical trialsGrowth factorsInflammationOsteoarthritisRegeneration |
| spellingShingle | Zuzana Macečková Jiří Pergner Martin Krbec Milan Urban Michal Zahradníček Application of amniotic membrane in osteoarthritis management Journal of Cartilage & Joint Preservation Amniotic membrane Clinical trials Growth factors Inflammation Osteoarthritis Regeneration |
| title | Application of amniotic membrane in osteoarthritis management |
| title_full | Application of amniotic membrane in osteoarthritis management |
| title_fullStr | Application of amniotic membrane in osteoarthritis management |
| title_full_unstemmed | Application of amniotic membrane in osteoarthritis management |
| title_short | Application of amniotic membrane in osteoarthritis management |
| title_sort | application of amniotic membrane in osteoarthritis management |
| topic | Amniotic membrane Clinical trials Growth factors Inflammation Osteoarthritis Regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2667254524000106 |
| work_keys_str_mv | AT zuzanamaceckova applicationofamnioticmembraneinosteoarthritismanagement AT jiripergner applicationofamnioticmembraneinosteoarthritismanagement AT martinkrbec applicationofamnioticmembraneinosteoarthritismanagement AT milanurban applicationofamnioticmembraneinosteoarthritismanagement AT michalzahradnicek applicationofamnioticmembraneinosteoarthritismanagement |