Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma
Paraneoplastic or ectopic Cushing’s syndrome (CS) is a rare cause of endogenous hypercortisolism. It is due to ectopic adrenocorticotropic hormone (ACTH) secretion and has been reported in association with a variety of neuroendocrine tumors such as small-cell lung carcinoma, carcinoid tumors, and me...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/5593920 |
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| author | R. Daya C. Wingfield P. Sotshononda F. Seedat S. Bulbulia M. D. Simmons M. Louw Z. Bayat |
| author_facet | R. Daya C. Wingfield P. Sotshononda F. Seedat S. Bulbulia M. D. Simmons M. Louw Z. Bayat |
| author_sort | R. Daya |
| collection | DOAJ |
| description | Paraneoplastic or ectopic Cushing’s syndrome (CS) is a rare cause of endogenous hypercortisolism. It is due to ectopic adrenocorticotropic hormone (ACTH) secretion and has been reported in association with a variety of neuroendocrine tumors such as small-cell lung carcinoma, carcinoid tumors, and medullary carcinoma of the thyroid. Paragangliomas (PGLs) are rare neuroendocrine tumors that can secrete catecholamines. Case reports and reports of ectopic ACTH secretion from metastatic PGLs causing CS are exceedingly rare. We present a case of a 38-year-old female, who presented with typical signs, symptoms, and complications of CS, secondary to a PGL with widespread metastases, which eventually led to her demise. |
| format | Article |
| id | doaj-art-1e0862a243964a1ba1d47fa8fc5cc2da |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-1e0862a243964a1ba1d47fa8fc5cc2da2025-08-20T03:54:34ZengWileyCase Reports in Endocrinology2090-65012090-651X2021-01-01202110.1155/2021/55939205593920Ectopic Cushing’s Syndrome Secondary to Metastatic ParagangliomaR. Daya0C. Wingfield1P. Sotshononda2F. Seedat3S. Bulbulia4M. D. Simmons5M. Louw6Z. Bayat7Division of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South AfricaDepartment of Anatomical Pathology, School of Pathology, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Anatomical Pathology, School of Pathology, University of the Witwatersrand, Johannesburg, South AfricaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Helen Joseph Hospital, 1 Perth Road, Rossmore, Johannesburg, South AfricaParaneoplastic or ectopic Cushing’s syndrome (CS) is a rare cause of endogenous hypercortisolism. It is due to ectopic adrenocorticotropic hormone (ACTH) secretion and has been reported in association with a variety of neuroendocrine tumors such as small-cell lung carcinoma, carcinoid tumors, and medullary carcinoma of the thyroid. Paragangliomas (PGLs) are rare neuroendocrine tumors that can secrete catecholamines. Case reports and reports of ectopic ACTH secretion from metastatic PGLs causing CS are exceedingly rare. We present a case of a 38-year-old female, who presented with typical signs, symptoms, and complications of CS, secondary to a PGL with widespread metastases, which eventually led to her demise.http://dx.doi.org/10.1155/2021/5593920 |
| spellingShingle | R. Daya C. Wingfield P. Sotshononda F. Seedat S. Bulbulia M. D. Simmons M. Louw Z. Bayat Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma Case Reports in Endocrinology |
| title | Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma |
| title_full | Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma |
| title_fullStr | Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma |
| title_full_unstemmed | Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma |
| title_short | Ectopic Cushing’s Syndrome Secondary to Metastatic Paraganglioma |
| title_sort | ectopic cushing s syndrome secondary to metastatic paraganglioma |
| url | http://dx.doi.org/10.1155/2021/5593920 |
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