Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis
A case of a 41-year-old woman with a history of nodular melanoma (NM), associated with an indurated dome-shaped blue-black nodule with a diameter of 1.2 cm in the gluteal region, is presented. Clinical diagnosis of the lesion, present from birth, was blue nevus. Recently, the nodule has been showing...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/8107671 |
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| author | Nives Jonjić Andrea Dekanić Nedeljka Glavan Larisa Prpić-Massari Blaženka Grahovac |
| author_facet | Nives Jonjić Andrea Dekanić Nedeljka Glavan Larisa Prpić-Massari Blaženka Grahovac |
| author_sort | Nives Jonjić |
| collection | DOAJ |
| description | A case of a 41-year-old woman with a history of nodular melanoma (NM), associated with an indurated dome-shaped blue-black nodule with a diameter of 1.2 cm in the gluteal region, is presented. Clinical diagnosis of the lesion, present from birth, was blue nevus. Recently, the nodule has been showing a mild enlargement and thus complete resection was performed. Histological analysis revealed a pigmented lesion with an expansive pattern of extension into the dermis and the subcutaneous adipose tissue. The lesion displayed an alveolar pattern as well as a pigmented dendritic cell pattern. The histology was consistent with cellular blue nevus (CBN); however, the history of NM which was excised one year earlier, as well as the clinical information about the slow growing lesion, included a differential diagnosis of CBN, borderline melanocytic tumor, and malignant blue nevus. Additional immunohistochemical (HMB-45, p16, and Ki-67) and molecular (BRAF V600E mutation) analyses were performed on both lesions: the CBN-like and the previously excised NM. Along with lesion history and histological analyses, p16 staining and BRAF were useful diagnostic tools for confirming the benign nature of CBN in this case. |
| format | Article |
| id | doaj-art-1dfa97819b8344b6a6e261a51d0ae3fc |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-1dfa97819b8344b6a6e261a51d0ae3fc2025-08-20T03:54:56ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/81076718107671Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in DiagnosisNives Jonjić0Andrea Dekanić1Nedeljka Glavan2Larisa Prpić-Massari3Blaženka Grahovac4Department of Pathology, Rijeka University School of Medicine, Braće Branchetta 20, 51000 Rijeka, CroatiaDepartment of Pathology, Rijeka University School of Medicine, Braće Branchetta 20, 51000 Rijeka, CroatiaDepartment of Pediatric Surgery, Rijeka University Hospital Center, Rijeka, CroatiaDepartment of Dermatovenerology, Rijeka University Hospital Center, Rijeka, CroatiaDepartment of Pathology, Rijeka University School of Medicine, Braće Branchetta 20, 51000 Rijeka, CroatiaA case of a 41-year-old woman with a history of nodular melanoma (NM), associated with an indurated dome-shaped blue-black nodule with a diameter of 1.2 cm in the gluteal region, is presented. Clinical diagnosis of the lesion, present from birth, was blue nevus. Recently, the nodule has been showing a mild enlargement and thus complete resection was performed. Histological analysis revealed a pigmented lesion with an expansive pattern of extension into the dermis and the subcutaneous adipose tissue. The lesion displayed an alveolar pattern as well as a pigmented dendritic cell pattern. The histology was consistent with cellular blue nevus (CBN); however, the history of NM which was excised one year earlier, as well as the clinical information about the slow growing lesion, included a differential diagnosis of CBN, borderline melanocytic tumor, and malignant blue nevus. Additional immunohistochemical (HMB-45, p16, and Ki-67) and molecular (BRAF V600E mutation) analyses were performed on both lesions: the CBN-like and the previously excised NM. Along with lesion history and histological analyses, p16 staining and BRAF were useful diagnostic tools for confirming the benign nature of CBN in this case.http://dx.doi.org/10.1155/2016/8107671 |
| spellingShingle | Nives Jonjić Andrea Dekanić Nedeljka Glavan Larisa Prpić-Massari Blaženka Grahovac Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis Case Reports in Pathology |
| title | Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis |
| title_full | Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis |
| title_fullStr | Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis |
| title_full_unstemmed | Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis |
| title_short | Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis |
| title_sort | cellular blue nevus diagnosed following excision of melanoma a challenge in diagnosis |
| url | http://dx.doi.org/10.1155/2016/8107671 |
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